Results 81 to 90 of about 586,058 (292)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Analysis of vehicle-type-specific headways on two-lane roads with mixed traffic

Transport, 2020
Time headway is an important microscopic traffic flow parameter, which affects safety, level-of-service, capacity and traffic simulation. It is, therefore, important to know the specific distribution for a particular roadway and traffic condition ...
Rupali Roy, Pritam Saha
doaj   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda, Hyo‐Min Kim, Nicole Battaglia, Joshua Rong, Amy Tam, Enrique Gonzalez Saez‐Diez, Cornelius F. Boerkoel, Afshin Saffari, Vicente Quiroz, Luca Schierbaum, Zainab Zaman, Katerina Bernardi, Darius Ebrahimi‐Fakhari   +12 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Dynamic lane-changing trajectory planning for autonomous vehicles in mixed traffic [PDF]

Artificial Intelligence and Autonomous Systems
This paper presents a novel dynamic lane-changing trajectory planning (DLCTP) model for autonomous vehicle (AV) running in the mixed traffic environment. The proposed model fully considers the dynamics of surrounding human-driven vehicles and can work on
Zhen Wang, Jianquan Chen, Pengchao Liu, Bo Dai, Guanqun Wang, Zhilin Han   +5 more
doaj   +1 more source

Comparison of Methods to Evaluate the Influence of an Automated Vehicle’s Driving Behavior on Pedestrians: Wizard of Oz, Virtual Reality, and Video

Information, 2020
Integrating automated vehicles into mixed traffic entails several challenges. Their driving behavior must be designed such that is understandable for all human road users, and that it ensures an efficient and safe traffic system.
Tanja Fuest, Elisabeth Schmidt, Klaus Bengler   +2 more
doaj   +1 more source

Traffic Prediction for Merging Coordination Control in Mixed Traffic Scenarios

Volume 2: Intelligent Transportation/Vehicles; Manufacturing; Mechatronics; Engine/After-Treatment Systems; Soft Actuators/Manipulators; Modeling/Validation; Motion/Vibration Control Applications; Multi-Agent/Networked Systems; Path Planning/Motion Control; Renewable/Smart Energy Systems; Security/Privacy of Cyber-Physical Systems; Sensors/Actuators; Tracking Control Systems; Unmanned Ground/Aerial Vehicles; Vehicle Dynamics, Estimation, Control; Vibration/Control Systems; Vibrations, 2020
Abstract Connected and autonomous vehicles (CAVs) have the potential to bring in safety, mobility, and energy benefits to transportation. The control decisions of CAVs are usually determined for a look-ahead horizon based on previewed traffic information.
Yunli Shao, Jackeline Rios-Torres
openaire   +2 more sources

Mixing it Up: Simulation of Mixed Traffic Container Terminals

2020 Winter Simulation Conference (WSC), 2020
The development from a completely manual brownfield terminal towards a highly automated one proceeds in a number of steps. To take the first steps, it is crucial to know how introducing Automated Yard Tractors (AYTs) influences port productivity at Mixed-Traffic Terminals (MTTs).
Gerrits, Berry, Mes, Martijn, Schuur, Peter   +2 more
openaire   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Multi-Vehicle Simulation in Urban Automated Driving: Technical Implementation and Added Benefit

Information, 2020
This article investigates the simultaneous interaction between an automated vehicle (AV) and its passenger, and between the same AV and a human driver of another vehicle.
Alexander Feierle, Michael Rettenmaier, Florian Zeitlmeir, Klaus Bengler   +3 more
doaj   +1 more source