Results 51 to 60 of about 568,985 (325)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Simulation Strategies for Mixed Traffic Conditions: A Review of Car-Following Models and Simulation Frameworks

Journal of Engineering, 2020
The area of traffic flow modelling and analysis that bridges civil engineering, computer science, and mathematics has gained significant momentum in the urban areas due to increasing vehicular population causing traffic congestion and accidents. Notably,
Bhargav Naidu Matcha, Satesh Narayana Namasivayam, Mohammad Hosseini Fouladi, K. C. Ng, Sivakumar Sivanesan, Se Yong Eh Noum   +5 more
doaj   +1 more source

Routing Control Optimization for Autonomous Vehicles in Mixed Traffic Flow Based on Deep Reinforcement Learning

Applied Sciences
With recent technological advancements, the commercialization of autonomous vehicles (AVs) is expected to be realized soon. However, it is anticipated that a mixed traffic of AVs and human-driven vehicles (HVs) will persist for a considerable period ...
Sung-woo Moon, Seolwon Koo, Y. Lim, Hyunjin Joo   +3 more
semanticscholar   +1 more source

Modeling Mixed Traffic Flow with Connected Autonomous Vehicles and Human-Driven Vehicles in Off-Ramp Diverging Areas

Sustainability, 2023
This paper focuses on modeling mixed traffic flow that comprises human-driven vehicles (HV), adaptive cruise control (ACC) vehicles, and cooperative adaptive cruise control (CACC) vehicles in the off-ramp diverging area.
Xiangquan Chen, Zhizhou Wu, Yunyi Liang
semanticscholar   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

A Day-to-Day Stochastic Traffic Flow Assignment Model Based on Mixed Regulation

IEEE Access, 2020
In many cases, the final path selection of travellers' is not the shortest path, due to the limited computing power and high cost of path search. To solve the problem, this paper proposes a day-to-day (DTD) stochastic traffic flow assignment model that ...
Lixuan Wu, Zhongxiang Huang, Jianhui Wu, Zhibo Gao, Dingming Qin   +4 more
doaj   +1 more source

Exploring the Distribution of Traffic Flow for Shared Human and Autonomous Vehicle Roads

Energies, 2021
In order to explore the changes that autonomous vehicles would bring to the current traffic system, we analyze the car-following behavior of different traffic scenarios based on an anti-collision theory and establish a traffic flow model with an ...
Huanping Li, Jian Wang, Guopeng Bai, Xiaowei Hu   +3 more
doaj   +1 more source

An Efficient Approach for Generalized Load Balancing in Multipath Packet Switched Networks

, 2010
This paper is a quantitative analysis on packet switched network with a view to generalize load balancing and determination of appropriate routing algorithm in multipath environment.
Alam, Md. Shihabul, Ali, G. G. Md. Nawaz, Chakraborty, Rajib, Chan, Edward   +3 more
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source