Results 101 to 110 of about 2,640,579 (332)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Mixing dynamics on the inner shelf of the Ebro Delta

Scientia Marina, 2012
Turbidity, CTD, and temperature and shear microstructure data recorded along a 25 km transect from 8 to 69 m depth across the Ebro Delta shelf (northwestern Mediterranean) are presented.
Imma Bastida, Jesús Planella, Elena Roget, Jorge Guillén, Pere Puig, Xavier Sánchez   +5 more
doaj   +1 more source

Rational weak mixing in infinite measure spaces

, 2013
Rational weak mixing is a measure theoretic version of Krickeberg's strong ratio mixing property for infinite measure preserving transformations. It requires "{\tt density}" ratio convergence for every pair of measurable sets in a dense hereditary ring ...
Aaronson, Bingham, Friedman, JON AARONSON, Karlin, Krickeberg   +5 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Numerical Simulation of Scalar Mixing and Transport through a Fishing Net Panel [PDF]

, 2022
Xinyue Yang, Xianglai Zeng, Carlo Gualtieri, Alan Cuthbertson, Ruo‐Qian Wang, Dongdong Shao   +5 more
openalex   +1 more source

Explanation of the Gibbs paradox within the framework of quantum thermodynamics

, 2006
The issue of the Gibbs paradox is that when considering mixing of two gases within classical thermodynamics, the entropy of mixing appears to be a discontinuous function of the difference between the gases: it is finite for whatever small difference, but
A. E. Allahverdyan, A. G. Butkovskiy, A. Landé, A. Peres, A. W. Marshall, C. A. Fuchs, D. Janzing, E. Schrödinger, E. Schrödinger, E. T. Jaynes, G. Lindblad, G. N. Bochkov, I. E. Tamm, J. Gemmer, J. Gemmer, J. Willard Gibbs, J. Willard Gibbs, L. A. Blumenfeld, L. D. Landau, M. O. Scully, N. G. van Kampen, P. Perrot, R. Balian, R. C. Tolman, Shu-Kun Lin, Th. M. Nieuwenhuizen, Th. M. Nieuwenhuizen, W. Thirring, Y. Rostovtsev, Ya. M. Gelfer, Yu. S. Varshavskii, Z. Sariyanni   +31 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source