Results 111 to 120 of about 2,640,579 (332)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Research on Structure and Characteristics of Gear System of Crossflow in Flow Domain of Reactor Core

open access: yesYuanzineng kexue jishu
The spatial difference of the thermal-hydraulic state in reactor core is easy to lead to local high temperature, so the risk of material burning and fuel melting is introduced under the safe conditions of average temperature. The fine computational fluid
CHEN Guangliang, ZHANG Hanqi, TAO Wenquan
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Provision Point-Source Materials Stimulates Play in Sows but Does Not Affect Aggression at Regrouping

open access: yesAnimals, 2018
When sows are mixed into groups, hierarchies form and resulting aggression and stress can affect production and welfare. This study determined the effect of providing point-source materials on aggressive and play behaviors in gestating sows.
Emma Catharine Greenwood   +4 more
doaj   +1 more source

CP Violation in $D^0-\overline{D^0}$Mixing

open access: yes, 1995
The existence of $D^0-\overline{D^0}$ mixing at a detectable level requires new physics, which effectively yields a $\Delta c = 2$ superweak interaction. In general this interaction may involve significant CP violation.
H. Georgi   +8 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Biocompatibility of a droplet-mixing device using an electro-conjugate fluid

open access: yesMechanical Engineering Journal, 2016
An electro-conjugate fluid (ECF) is a type of functional fluid that produces a jet flow under a non-uniform electric field. We use an ECF to generate a rotational flow in a tiny cylindrical chamber.
Kenjiro TAKEMURA   +2 more
doaj   +1 more source

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