Results 61 to 70 of about 824,815 (299)

Simulation of the Advection Process of Stokes Flow Inside a Rectangular Cavity Under Constant Velocities

open access: yesAxioms
A two-dimensional periodic Stokes flow of viscous incompressible fluid in a rectangular cavity with constant velocities applied to the top and bottom walls is considered. The study of advection regimes is reduced to the sequential solving of two problems.
Valentyn Sobchuk   +6 more
doaj   +1 more source

Localisation of Vertical Auditory Phantom Image with Band-limited Reductions of Vertical Interchannel Crosstalk

open access: yesApplied Sciences, 2020
Direct sound that is captured by the upper layer of a three-dimensional (3D) microphone array is typically regarded as vertical interchannel crosstalk (VIC), since it tends to produce an undesired effect of the sound source image being elevated from the ...
Rory Wallis, Hyunkook Lee
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Altitude Profile and Isotopic Composition for N2 From Pioneer Venus Mass Spectra

open access: yesGeophysical Research Letters
We report the highest resolution altitude profile and isotopic composition for N2 at Venus, to date. These results were obtained through re‐analysis of data acquired by the Pioneer Venus Large Probe Neutral Mass Spectrometer (LNMS).
R. Mogul, S. S. Limaye, M. J. Way
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Consistency issues in PDF methods

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2015
Concentrations of chemical species transported in random environments need to be statistically characterized by probability density functions (PDF).
Suciu N.   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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