Results 41 to 50 of about 193,007 (199)

Investigation of Vertical Profiles of Meteorological Parameters and Ozone Concentration in the Mexico City Metropolitan Area

Asian Journal of Atmospheric Environment, 2015
In the Mexico City Metropolitan Area (MCMA), ozone (O3) concentration is still higher than in other urban areas in developed countries. In order to reveal the current state of photochemical air pollution and to provide data for validation of chemical ...
Sandy E. Benitez-Garcia, Isao Kanda, Yukiyo Okazaki, Shinji Wakamatsu, Roberto Basaldud, Nobuji Horikoshi, Jose A. Ortinez, Victor R. Ramos-Benitez, Beatriz Cardenas   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Observation Path Problems and the Formation Conditions of the Elevated Layer of Black Carbon Aerosol

Atmosphere, 2020
Studies on the detection of layers with elevated black carbon aerosol (BC) concentrations and the formation conditions of these layers help understand the vertical distribution of BC concentrations, which will provide a basis for the assessment of ...
Lianji Jin, Liang Lin, Deping Ding, Delong Zhao, Bin Zhu, Qingfei Zhai, Zheng Liu   +6 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Analysis of laminar-turbulent transition process in mixing layer with various information measures

Nihon Kikai Gakkai ronbunshu, 2016
In the laminar-turbulent transition process of a mixing layer formed downstream of a two-dimensional nozzle exit, an analysis was performed based on various information measures.
Masashi ICHIMIYA, Ikuo NAKAMURA
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Numerical Simulation of Hydrate Dissociation Behaviors in Hydrate Reservoir with Different Properties during Horizontal Well Drilling

Journal of Marine Science and Engineering
The effectiveness of horizontal well drilling in improving the gas recovery efficiency of hydrate production makes it a promising technology for commercial exploitation.
Fei Gao, Yu Zhang, Chang Chen, Xiaosen Li, Zhaoyang Chen   +4 more
doaj   +1 more source

Groundwater monitoring of an open-pit limestone quarry: Water-rock interaction and mixing estimation within the rock layers by geochemical and statistical analyses

International Journal of Mining Science and Technology, 2018
Water-rock interaction and groundwater mixing are important phenomena in understanding hydrogeological systems and the stability of rock slopes especially those consisting largely of moderately water-soluble minerals like calcite.
Khy Eam Eang, Toshifumi Igarashi, Megumi Kondo, Tsurugi Nakatani, Carlito Baltazar Tabelin, Ryota Fujinaga   +5 more
doaj   +1 more source

A conceptual framework to quantify the influence of convective boundary layer development on carbon dioxide mixing ratios [PDF]

Atmospheric Chemistry and Physics, 2012
Interpretation of observed diurnal carbon dioxide (CO₂) mixing ratios near the surface requires knowledge of the local dynamics of the planetary boundary layer.
D. Pino, J. Vilà-Guerau de Arellano, W. Peters, J. Schröter, C. C. van Heerwaarden, M. C. Krol   +5 more
doaj   +1 more source