Results 61 to 70 of about 839,766 (302)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Investigation of Vertical Profiles of Meteorological Parameters and Ozone Concentration in the Mexico City Metropolitan Area

Asian Journal of Atmospheric Environment, 2015
In the Mexico City Metropolitan Area (MCMA), ozone (O3) concentration is still higher than in other urban areas in developed countries. In order to reveal the current state of photochemical air pollution and to provide data for validation of chemical ...
Sandy E. Benitez-Garcia, Isao Kanda, Yukiyo Okazaki, Shinji Wakamatsu, Roberto Basaldud, Nobuji Horikoshi, Jose A. Ortinez, Victor R. Ramos-Benitez, Beatriz Cardenas   +8 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Observation Path Problems and the Formation Conditions of the Elevated Layer of Black Carbon Aerosol

Atmosphere, 2020
Studies on the detection of layers with elevated black carbon aerosol (BC) concentrations and the formation conditions of these layers help understand the vertical distribution of BC concentrations, which will provide a basis for the assessment of ...
Lianji Jin, Liang Lin, Deping Ding, Delong Zhao, Bin Zhu, Qingfei Zhai, Zheng Liu   +6 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Analysis of laminar-turbulent transition process in mixing layer with various information measures

Nihon Kikai Gakkai ronbunshu, 2016
In the laminar-turbulent transition process of a mixing layer formed downstream of a two-dimensional nozzle exit, an analysis was performed based on various information measures.
Masashi ICHIMIYA, Ikuo NAKAMURA
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A conceptual framework to quantify the influence of convective boundary layer development on carbon dioxide mixing ratios [PDF]

Atmospheric Chemistry and Physics, 2012
Interpretation of observed diurnal carbon dioxide (CO₂) mixing ratios near the surface requires knowledge of the local dynamics of the planetary boundary layer.
D. Pino, J. Vilà-Guerau de Arellano, W. Peters, J. Schröter, C. C. van Heerwaarden, M. C. Krol   +5 more
doaj   +1 more source

Increasing vertical mixing to reduce Southern Ocean deep convection in NEMO3.4 [PDF]

, 2015
Most CMIP5 (Coupled Model Intercomparison Project Phase 5) models unrealistically form Antarctic Bottom Water by open ocean deep convection in the Weddell and Ross seas.
Calvert, D., Heuzé, C., Heywood, K. J., Ridley, J. K., Stevens, D. P.   +4 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source