Results 71 to 80 of about 839,766 (302)

Numerical Simulation of Hydrate Dissociation Behaviors in Hydrate Reservoir with Different Properties during Horizontal Well Drilling

Journal of Marine Science and Engineering
The effectiveness of horizontal well drilling in improving the gas recovery efficiency of hydrate production makes it a promising technology for commercial exploitation.
Fei Gao, Yu Zhang, Chang Chen, Xiaosen Li, Zhaoyang Chen   +4 more
doaj   +1 more source

Groundwater monitoring of an open-pit limestone quarry: Water-rock interaction and mixing estimation within the rock layers by geochemical and statistical analyses

International Journal of Mining Science and Technology, 2018
Water-rock interaction and groundwater mixing are important phenomena in understanding hydrogeological systems and the stability of rock slopes especially those consisting largely of moderately water-soluble minerals like calcite.
Khy Eam Eang, Toshifumi Igarashi, Megumi Kondo, Tsurugi Nakatani, Carlito Baltazar Tabelin, Ryota Fujinaga   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Redefining Mixing Length in Turbulent Mixing Layer in Terms of Shear-Induced Vorticity

Journal of Fluid Science and Technology, 2011
An incompressible turbulent planar mixing layer is composed of two different flow types in its flow field, namely a shear layer in the central region and two free streams in each outer high- and low-speed sides.
Keh-Chin CHANG, Chiuan-Ting LI
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Flow Field Characteristics of High‑Gradient Mixing Layers and Laws of Energy Transfer

Nanjing Hangkong Hangtian Daxue Xuebao
A numerical simulation study is conducted on the flow field characteristics and laws of energy transfer of the high-gradient mixing layer in a rocket-assisted ramjet engine （RARE） .
YANG Yiding, ZHANG Jingyu, LIU Ming, HE Xiaomin   +3 more
doaj   +1 more source

Flow structure within a vegetation patch in a gravel-bed river

Journal of Hydrology and Hydromechanics, 2019
Investigation of the interactions between submerged vegetation patch and flow structure is of crucial importance for river engineering. Most of hydraulic models have been presented for fully developed flows over uniform vegetation in the laboratory ...
Jahadi Mahsa, Afzalimehr Hossein, Rowinski Paweł M.   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Cluster-based reduced-order modelling of a mixing layer

, 2014
We propose a novel cluster-based reduced-order modelling (CROM) strategy of unsteady flows. CROM combines the cluster analysis pioneered in Gunzburger's group (Burkardt et al.
Abel, Markus, Cordier, Laurent, Daviller, Guillaume, Kaiser, Eurika, Krajnović, Siniša, Niven, Robert K., Noack, Bernd R., Segond, Marc, Spohn, Andreas, Östh, Jan   +9 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source