Understanding the shape of the mixture failure rate (with engineering and demographic applications) [PDF]
Mixtures of distributions are usually effectively used for modeling heterogeneity. It is well known that mixtures of DFR distributions are always DFR. On the other hand, mixtures of IFR distributions can decrease, at least in some intervals of time.
Maxim S. Finkelstein
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mixture-Quantitative Structure-Property Relationship Approaches for Jet Fuel-Component Blends: A Review. [PDF]
Mol InformYeghyan E, Creton B, Matrat M, Marcou G.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Finite Mixture Analysis of Beauty-Contest Data from Multiple Samples [PDF]
This paper develops a finite mixture distribution analysis of Beauty- Contest data obtained from diverse groups of experiments. ML estimation using the EM approach provides estimates for the means and variances of the component distributions, which are ...
Rosmarie Nagel +3 more
core
Performance of Asphalt Mixtures Hybrid-Modified with Industrial Diatomite By-Products and Different Microfibres. [PDF]
Polymers (Basel)Aslan MT +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Mechanical, Durability, Carbon Footprint, and Economic Assessment of Sand-Gravel-Gneiss Aggregate Mixtures for Sustainable Road Construction. [PDF]
Materials (Basel)Nowaczek A +6 more
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source