Results 101 to 110 of about 15,978 (252)

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Bayesian Optimization With GPU Acceleration for Ocean Models

Journal of Geophysical Research: Machine Learning and Computation
Ocean general circulation models (OGCMs) contain numerous parameterizations of subgrid scale processes. The parameter tuning procedure is rarely reported and often done by hand.
Marta Agnieszka Mrozowska, James Avery, Aster Stoustrup, Roman Nuterman, Carl‐Johannes Johnsen, Asger Thormann, Markus Jochum   +6 more
doaj   +1 more source

Impact of Mutational Landscape and Burden on RBC Transfusion Response in Patients With Lower‐Risk Myelodysplastic Syndromes (LR‐MDS) in the COMMANDS Study

American Journal of Hematology, Volume 101, Issue 3, Page 427-438, March 2026.
ABSTRACT The COMMANDS trial established luspatercept as a first‐line treatment for anemia in transfusion‐dependent lower‐risk (LR) myelodysplastic syndromes (MDS). Here we report red blood cell (RBC) transfusion response analysis based on somatic mutations profile and disease risk for patients treated with luspatercept or epoetin alfa in the COMMANDS ...
Rami S. Komrokji, Sheida Hayati, Manuel Ugidos, Guillermo Garcia‐Manero, Matteo Giovanni Della Porta, Amer M. Zeidan, Valeria Santini, Uwe Platzbecker, Anita K. Gandhi, Rajasekhar N. V. S. Suragani   +9 more
wiley   +1 more source

Inconsistency between mixed layer depth and near sea surface stratification over the global ocean

Environmental Research Letters
Mixed layer depth (MLD) and near-surface stratification (derived from bulk and subskin density) are crucial variables for defining stability within the upper ocean. Conventional paradigms generally describe the relationship between MLD and stratification
Hao Liu, Xunwei Nie, Tengfei Xu, Dingqi Wang, Chaoran Cui, Qiuli Shao, Yunzhou Li, Xun Gong, Zexun Wei   +8 more
doaj   +1 more source

Modeling of Mixed Logical Dynamical (MLD) Model to Hybrid Three Tank System

, 2015
Vinod Phani, Cyril Joseph, Satya Narayan Agarwal   +2 more
openalex   +1 more source

41. Ex Vivo Gene Therapy Provides a Unique Therapeutic Benefit and Corrects Metachromatic (MLD) and Globoid (GLD) Leukodystrophy in the Mouse Models [PDF]

, 2004

openalex   +1 more source

Mesoscale Circulation and Coral Community Disturbance at Isolated Reefs

Global Change Biology Communications, Volume 1, Issue 1, March 2026.
The Loop Current is a seasonally and interannually dynamic mesoscale oceanographic feature in the Gulf of Mexico that strongly influences connectivity and environmental conditions across the region. We investigated the influence of Loop Current variability on coral reef disturbances at isolated reefs in the northwest Gulf, including coral disease ...
Gaby E. Carpenter, Benjamin H. Farmer, Hannah E. Craft, Amy Apprill, Marilyn E. Brandt, Adrienne M. S. Correa, Laura D. Mydlarz, Daniel M. Holstein   +7 more
wiley   +1 more source

Rapport de Mission MLD Pascal Raux (UBO UMR AMURE) dans le cadre du LMI LIMAQUA du 17/10/2023 au 13/12/2023 (Afrique du Sud et Kenya) [PDF]

, 2023
Pascal Raux
openalex  

Quantifying interactive photochemical and microbial removal of terrestrial dissolved organic carbon: From experiments to modeling

Limnology and Oceanography Letters, Volume 11, Issue 2, March 2026.
Abstract The biogeochemical fate of terrestrial dissolved organic carbon (tDOC) in aquatic environments is a poorly understood part of the carbon cycle. In nature, tDOC undergoes photochemical and microbial degradation simultaneously. However, photochemical and microbial degradation are generally quantified separately, and nonlinear interactions ...
Patrick Martin, Oon Yee Woo, Yuan Chen, Clement Y. Tan, Crystal T. Yang, Yongli Zhou, Bernhard Mayer   +6 more
wiley   +1 more source

Inventory of current practices regarding hematopoietic stem cell transplantation in metachromatic leukodystrophy in Europe and neighboring countries

Orphanet Journal of Rare Diseases
Background For decades, early allogeneic stem cell transplantation (HSCT) has been used to slow neurological decline in metachromatic leukodystrophy (MLD). There is lack of consensus regarding who may benefit, and guidelines are lacking.
Daphne H. Schoenmakers, Fanny Mochel, Laura A. Adang, Jaap-Jan Boelens, Valeria Calbi, Erik A. Eklund, Sabine W. Grønborg, Francesca Fumagalli, Samuel Groeschel, Caroline Lindemans, Caroline Sevin, Ludger Schöls, Dipak Ram, Ayelet Zerem, Holm Graessner, Nicole I. Wolf   +15 more
doaj   +1 more source