Results 41 to 50 of about 32,374 (267)

The plasmid-host fitness landscape: a new paradigm for predicting the fate of mobile resistance

Applied and Environmental Microbiology
The widespread persistence of antimicrobial resistance (AMR) plasmids presents a fundamental challenge to microbial evolution, known as the “plasmid paradox”: if these plasmids cause fitness cost, why are they not eliminated by selection?
Hevar N. Abdulqadir
doaj   +1 more source

Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins

Antibiotics, 2023
Enterococci are troublesome nosocomial, opportunistic Gram-positive cocci bacteria showing enhanced resistance to many commonly used antibiotics. This study aims to investigate the prevalence and genetic basis of antibiotic resistance to macrolides ...
Amr Selim Abu Lila, Tareq Nafea Alharby, Jowaher Alanazi, Muteb Alanazi, Marwa H. Abdallah, Syed Mohd Danish Rizvi, Afrasim Moin, El-Sayed Khafagy, Shams Tabrez, Abdullah Ali Al Balushi, Wael A. H. Hegazy   +10 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

UV-VIS laser parameter effects on the physicochemical properties of Laser-Induced Graphene

Universitas Scientiarum
Laser-induced graphene (LIG) is a versatile and scalable technique for the low-cost production of graphene-like sensing devices. However, the performance of these devices is hypersensitive to the engraving parameters used during fabrication. In this work,
Jhonattan de la Roche, Carlos Lubo Mestanza, Laura Tenjo Patiño, Santiago Lasso, Santiago Ospina Arroyave, Sebastián Mendoza, Lucero Alvarez Mino   +6 more
doaj   +1 more source

Will Adding Michel’s Solution to the Laboratory Reagents do Any Good for the Neuropathologists?

BioMedica, 2023
The importance of intraoperative consultation through frozen sections can hardly be over-emphasized. The overall accuracy of frozen section diagnosis falls within the range of 92% to 97.98%; however, in brain tissues, the diagnostic accuracy is debatable,
Tuaha Amjad, Muhammad Hassan Malik, Ghulam Rasool, Shameen Shoaib   +3 more
doaj   +1 more source

On the Value of ML Models

CoRR, 2021
We argue that, when establishing and benchmarking Machine Learning (ML) models, the research community should favour evaluation metrics that better capture the value delivered by their model in practical applications. For a specific class of use cases -- selective classification -- we show that not only can it be simple enough to do, but that it has ...
Fabio Casati, Pierre-André Noël, Jie Yang 0028   +2 more
openaire   +3 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Brain Midline Shift Measurement and Its Automation: A Review of Techniques and Algorithms

International Journal of Biomedical Imaging, 2018
Midline shift (MLS) of the brain is an important feature that can be measured using various imaging modalities including X-ray, ultrasound, computed tomography, and magnetic resonance imaging.
Chun-Chih Liao, Ya-Fang Chen, Furen Xiao
doaj   +1 more source

The Caenorhabditis elegans T-box factor MLS-1 requires Groucho co-repressor interaction for uterine muscle specification. [PDF]

PLoS Genetics, 2011
T-box proteins are conserved transcription factors that play crucial roles in development of all metazoans; and, in humans, mutations affecting T-box genes are associated with a variety of congenital diseases and cancers.
Raymond R Miller, Peter G Okkema
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source