Results 311 to 320 of about 396,778 (337)

MMPs Inhibitors: New Succinylhydroxamates with Selective Inhibition of MMP‐2 over MMP‐3.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Valérie, Marcq, Catherine, Mirand, Martine, Decarme, Hervé, Emonard, William, Hornebeck   +4 more
openaire   +2 more sources

Genes expression of metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis

Russian Journal of Genetics, 2011
Using real-time polymerase chain reaction (RT-PCR), we measured mRNA amounts of matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-9, and MMP-12 genes in psoriatic lesions and unaffected skin of the same patients. We observed significant (about 15-fold) increase in the expression level of matrix metalloproteinase MMP-1 and MMP-12 genes associated with
N. L. Starodubtseva, V. V. Sobolev, A. G. Soboleva, A. A. Nikolaev, S. A. Bruskin   +4 more
openaire   +1 more source

Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3

Bioorganic & Medicinal Chemistry Letters, 2003
Phosphinic acid-based inhibitors of MMP-13 have been investigated with the aim of identifying potent inhibitors with high selectivity versus MMP-1. Independent variation of the substituents on a P(1)' phenethyl group and a P(2) benzyl group improved potencies in both cases around 3-fold over the unsubstituted parent.
Lawrence A, Reiter, Peter G, Mitchell, Gary J, Martinelli, Lori L, Lopresti-Morrow, Sue A, Yocum, James D, Eskra   +5 more
openaire   +2 more sources

Matrix metalloproteinases MMP-2, MMP-7 and MMP-9 in denervated human muscle

NeuroReport, 1999
Proteolytic enzyme expression was studied by matrix metalloproteinases (MMP) immunoreactivity (-IR) in muscle biopsies from patients with amyotrophic lateral sclerosis (ALS), spinal muscle atrophy (SMA) and chronic axonal neuropathies (CANP). In normal muscle MMP-2-, MMP-7-, and MMP-9-IR was localized at neuromuscular junctions, in vessels and nerve ...
B G, Schoser, D, Blottner
openaire   +2 more sources

Cellular sources of MMP-7, MMP-13 and MMP-28 in ulcerative colitis

Scandinavian Journal of Gastroenterology, 2010
Matrix metalloproteinases (MMPs) are considered the predominant proteases in the pathogenesis of mucosal ulcerations associated with inflammatory bowel disease (IBD). Whether the malignancy associated MMP-7 and MMP-13 or the recently cloned MMP-28 convey a certain meaning for intestinal homeostasis and pathogenesis of IBD is currently unknown.
Timo, Rath, Martin, Roderfeld, Jörg Michael, Halwe, Annette, Tschuschner, Elke, Roeb, Jürgen, Graf   +5 more
openaire   +2 more sources

Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression

Journal of Dermatological Science, 2001
Stasis dermatitis is a common disorder, which is a consequence of impaired venous drainage of the legs. It is characterized histologically by proliferation of small blood vessels in the papillary dermis. This neovascularization may lead occasionally to the formation of discrete papules due to inflammatory processes.
Herouy, Yared, Mellios, Philipp, Bandemir, Ellen, Dichmann, Stefan, Nockowski, Piotr, Schöpf, Erwin, Norgauer, Johannes   +6 more
openaire   +3 more sources

MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2015
Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms, of which OSCC has a worse prognosis. Matrix metalloproteinases (MMPs) are involved in the initiation, invasion, metastasis, and defense of cancer.
Salo Tuula, Haglund Caj, Hagstrom Jaana, Kontio Risto, Virolainen Susanna, Atula Timo, Sorsa Timo, Salo Tuula, Häyry Valtteri, Salo Tuula, Haglund Caj, Hagstrom Jaana, Kontio Risto, Virolainen Susanna, Atula Timo, Sorsa Timo, Salo Tuula, Häyry Valtteri   +17 more
openaire   +2 more sources

MMP-14 aktiviert MMP-2 und MMP-13 in vivo

Zeitschrift für Gastroenterologie, 2004
E Meyer, I Conrad, D Friebe, P Czochra, F Garcia-Lazaro, FR Thieringer, P Galle, M Blessing, A Lohse, S Kanzler   +9 more
openaire   +1 more source

[Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis].

Genetika, 2011
Using real-time polymerase chain reaction (RT-PCR), we measured mRNA amounts of matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-9, and MMP-12 genes in psoriatic lesions and unaffected skin of the same patients. We observed significant (about 15-fold) increase in the expression level of matrix metalloproteinase MMP-1 and MMP-12 genes associated with
N L, Starodubtseva, V V, Sobolev, A G, Soboleva, A A, Nikolaev, S A, Bruskin   +4 more
openaire   +1 more source

MMPs

2021
openaire   +1 more source