Results 41 to 50 of about 303,037 (241)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Mn(II) Oxidation by the Multicopper Oxidase Complex Mnx: A Coordinated Two-Stage Mn(II)/(III) and Mn(III)/(IV) Mechanism [PDF]

Journal of the American Chemical Society, 2017
The bacterial manganese oxidase MnxG of the Mnx protein complex is unique among multicopper oxidases (MCOs) in carrying out a two-electron metal oxidation, converting Mn(II) to MnO2 nanoparticles. The reaction occurs in two stages: Mn(II) → Mn(III) and Mn(III) → MnO2.
Alexandra V. Soldatova, Christine A. Romano, Lizhi Tao, Troy A. Stich, William H. Casey, R. David Britt, Bradley M. Tebo, Thomas G. Spiro   +7 more
openaire   +4 more sources

Sustainable Downscaled Catalytic Colorimetric Determination of Manganese in Freshwater Using Smartphone-Based Monitoring Oxidation of 3,3′,5,5′-Tetramethylbenzidine by Periodate

Molecules, 2022
A sustainable downscaled procedure using smartphone-based colorimetric determination of manganese (Mn(II)) was developed. This novel Mn(II) determination procedure is proposed using a simple, available microwell-plate platform and a smartphone as a ...
Sutasinee Apichai, Parichart Kummuntakoon, Thanawat Pattananandecha, Jakaphun Julsrigival, Kasirawat Sawangrat, Fumihiko Ogata, Naohito Kawasaki, Kate Grudpan, Chalermpong Saenjum   +8 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The bradykinin B2 receptor induces multiple cellular responses leading to the proliferation of human renal carcinoma cell lines

Cancer Management and Research, 2012
Inga I Kramarenko1, Thomas A Morinelli1,2, Marlene A Bunni1,2, John R Raymond Sr3, Maria N Garnovskaya11Department of Medicine (Nephrology Division), Medical University of South Carolina, Charleston, SC, USA; 2Medical and Research Services of the Ralph H
Kramarenko II, Morinelli TA, Bunni MA, Raymond JR Sr, Garnovskaya MN   +4 more
doaj  

Oxidative Formation and Removal of Complexed Mn(III) by Pseudomonas Species

Frontiers in Microbiology, 2018
The observation of significant concentrations of soluble Mn(III) complexes in oxic, suboxic, and some anoxic waters has triggered a re-evaluation of the previous Mn paradigm which focused on the cycling between soluble Mn(II) and insoluble Mn(III,IV ...
Mitchell H. Wright, Kati Geszvain, Véronique E. Oldham, Véronique E. Oldham, George W. Luther, Bradley M. Tebo   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

(II) PREPARATION AND CHARACTERIZATION OF MN (III) COMPLEXES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1992
We have prepared and characterized a few Mn (III) complexes by using a few bidentate and tridentate ligands. Spectra of the manganese (Abstract We have prepared and characterized a few Mn (III) complexes by using a few bidentate and tridentate ligands ...
doaj  

Bifunctional catalase-peroxidase KatB drives direct and indirect Mn(II) oxidation in genetically engineered bacteria: Synergistic biochar immobilization enhances wastewater remediation

Environment International
Manganese (Mn) pollution threatens ecosystems and human health. Microbial Mn(II) oxidation is a promising Mn(II) removal strategy, which converts soluble Mn(II) into insoluble Mn(III/IV) oxides.
Wentao Mo, Huiting Mei, Shizhen Liu, Shuang Cheng, Yue Wang, Jianghan Wang, Jin He, Jianmei Su   +7 more
doaj   +1 more source