Results 61 to 70 of about 303,037 (241)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with ligand formed by condensation reaction of isatin with glutamic acid

Eclética Química, 2020
The complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with ligand (H2L=C13H12N2O5) formed by condensation reaction of isatin and glutamic acid were synthesized. Their physico-chemical properties were characterized using elemental analysis, XRF, XRD,
Wiesława Ferenc, Dariusz Osypiuk, Jan Sarzyński, Halina Głuchowska   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

THE INFLUENCE OF pH TOWARDS MULTIPLE METAL ION ADSORPTION OF Cu(II), Zn(II), Mn(II), AND Fe(II) ON HUMIC ACID

Indonesian Journal of Chemistry, 2010
Multiple metal ions adsorption of Cu(II), Zn(II), Mn(II) and Fe(II) on humic acid with a batch method has been carried out at pH interaction of 3, 5, and 6.
Buhani Buhani, Suharso Suharso
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Crystal Structures, Magnetic Properties, and Redox Behaviors of Carboxylato-Bridged Mn(II) Complexes with Ditopic Ligands Featuring N₃-Coordination Sites

Chemistry
Carboxylato-bridged dinuclear and tetranuclear Mn(II) complexes 1–3 with ditopic ligands featuring two N3-terminal coordination sites connected by hexyl (tphn), octyl (tpon), and p-xylyl (tpxn) linkers have been synthesized and characterized through X ...
Junya Sugiyama, Yusuke Umemoto, Sota Sato, Ko Yoneda, Masayuki Koikawa   +4 more
doaj   +1 more source

Fe(II) reduction of pyrolusite (β-MnO2) and secondary mineral evolution

Geochemical Transactions, 2017
Iron (Fe) and manganese (Mn) are the two most common redox-active elements in the Earth’s crust and are well known to influence mineral formation and dissolution, trace metal sequestration, and contaminant transformations in soils and sediments. Here, we
Michael V. Schaefer, Robert M. Handler, Michelle M. Scherer   +2 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Synthesis And Spectral Study Of Cr(Iii), Mn(Ii), Ni(Ii) And Cu(Ii) Complexes Of Schiff Base Derived From Diacetylmonoxime With Thiourea

مجلة العلوم البحتة والتطبيقية, 2020
Transition metal complexes of Cr(III), Mn(II), Ni(II) and Cu(II) of the Schiff base; 1-((2E,3E)-3-(hydroxyimino)butan-2-ylidene)thiourea were synthesized and characterized on the basis of physical characteristics, molar conductivity, micro-analytical ...
K. M. Khalifa, A. M. Hamil, A. R. Aluwah
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source