Results 181 to 190 of about 138,791 (334)

TKC‐MC: An Effective Strategy for Generating Heritable Heterozygous Mutations in Essential Genes in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT The CRISPR/Cas9 gene‐editing technology has been widely used in defining gene functions and crop improvement. However, some genes are essential for plant growth and development. Loss‐of‐function homozygous mutations in essential genes lead to plant death or sterility.
Meilian Xu, Lang Yan, Min Zhu, Zhitian Zhan, Hong Chen, Dantong Wang, Zhenping Zheng, Yujie Zhang, Lizhong Xiong, Yubing He   +9 more
wiley   +1 more source

A self-supervised machine learning pipeline for extracting information from live cell images at multiple doses and timepoints. [PDF]

Sci Rep
Isaev DY, Liu WP, Cuevas M, Tang Y, Ang K, Wilson C, Mai Q, Adra J, Cruz A, Nguyen K, Ricasa M, Gupta A, Hamadani M, Sridharan D, Yeghiazarians Y, Ameri K.   +15 more
europepmc   +1 more source

Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations.

Mutagenesis, 2016
J. Wills, G. Johnson, S. Doak, Lya G. Soeteman-Hernández, W. Slob, P. White   +5 more
semanticscholar   +1 more source

Haplotype‐Resolved Genome Assembly and Population Genomics Reveal Evolutionary History and Agronomic Traits of Mulberry

Plant Biotechnology Journal, EarlyView.
ABSTRACT Mulberry is a representative economic tree species valued for both poverty alleviation and medicinal use. To advance the understanding of mulberry genomics and demography, we assembled high‐quality haploid genomes of two widely cultivated mulberry varieties NS14 and QS1, and analysed 376 accessions from 12 countries, including 39 ancient trees
Zhifeng Wang, Peigang Liu, Chengzhi Jiao, Yazhou Zhang, Zilong Xu, Tianbao Lin, Yan Zhu, Xin Jing, Yuan Huang, Nan Chao, Mengjie Zhao, Yan Liu, Huizi Liu, Bo Sun, Fen Zhang, Quanzi Li, Zhiqiang Lv, Xuepeng Sun, Ying‐Chung Jimmy Lin, Jia Wei   +19 more
wiley   +1 more source

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis. [PDF]

Nat Commun
Bond AN, Orzechowski M, Zhang S, Ben-Zion I, Lemmer A, Garry N, Lee K, Chen M, Delano K, Gath E, Golas AL, Nietupski R, Fitzgerald M, Ehrt S, Rubin EJ, Sassetti CM, Schnappinger D, Shoresh N, Hunt DK, Gomez JE, Hung DT.   +20 more
europepmc   +1 more source

Linking behaviour change techniques to mechanisms of action: Using the Theory and Techniques Tool alongside the Behaviour Change Intervention Ontology. [PDF]

Wellcome Open Res
Zhang L, Schenk PM, Santilli M, Wright AJ, Marques MM, Johnston M, West R, Michie S.   +7 more
europepmc   +1 more source

First nuclear genome assembly of an extinct moa species, the little bush moa (Anomalopteryx didiformis)

bioRxiv, 2018
Alison Cloutier, Timothy B Sackton, P. Grayson, S. Edwards, A. Baker   +4 more
semanticscholar   +1 more source

A MaERF110‐MaMYB308 Transcriptional Module Negatively Regulates Lignin‐Mediated Defence Against Fusarium Wilt in Banana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Fusarium wilt of banana (FWB), caused by Fusarium oxysporum f. sp. cubense (Foc), threatens global banana production. Lignin reinforces cell walls against pathogens and lodging, yet its regulatory mechanisms in banana remain elusive. Through genome‐wide association study (GWAS) of lignin content across 184 banana accessions, we identified ...
Yuqi Li, Yulin Hu, Weijun Xiao, Liu Yan, Junting Feng, Miaomiao Cao, Yanlin Si, Jinhan Lyu, Yankun Zhao, Kai Li, Yongzan Wei, Huigang Hu, Wei Li, Peitao Lü, Wei Wang, Zhenhai Han, Jianghui Xie   +16 more
wiley   +1 more source

A 3D-Printed Transoral Guide Device to Aid Single-Person Fiberoptic Intubation: A Randomized Clinical Trial. [PDF]

Med Sci Monit
Wu T, Dong M, Sui H, Chen W, Wang Y, Chen Y.   +5 more
europepmc   +1 more source

Moa diet fits the bill: virtual reconstruction incorporating mummified remains and prediction of biomechanical performance in avian giants

Proceedings of the Royal Society B: Biological Sciences, 2016
M. Attard, L. A. Wilson, T. Worthy, P. Scofield, P. Johnston, W. Parr, S. Wroe   +6 more
semanticscholar   +1 more source