Results 51 to 60 of about 83,177 (340)

Mode of Action (MOA) Assignment Classifications for Ecotoxicology: An Evaluation of Approaches.

Environmental Science and Technology, 2017
The mode of toxic action (MOA) is recognized as a key determinant of chemical toxicity and as an alternative to chemical class-based predictive toxicity modeling.
A. Kienzler, M. Barron, S. Belanger, A. Beasley, M. Embry   +4 more
semanticscholar   +1 more source

OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice

Advanced Science, EarlyView.
OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang, Aaron Chan, Yongyi Fan, Yanwu Wang, Pao Xue, Yingxin Zhang, Xiaodeng Zhan, Weixun Wu, Ping Yu, Daibo Chen, Junlin Fu, Yongbo Hong, Xihong Shen, Lianping Sun, Aike Zhu, Shihua Cheng, Qunen Liu, Liyong Cao   +17 more
wiley   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Quantifying the Dynamics of Network Detachment Across Scientific, Technological, Commercial, and Pharmacological Domains

Advanced Science, EarlyView.
Across scientific, technological, commercial, and pharmacological domains, individuals and organizations disengage from a previously adopted practice not at random, but as their network neighbors detach. The probability of detachment rises with the number of neighbors who have already disengaged. Preferential detachment reshapes network disintegration,
Binglu Wang, Ching Jin, Chaoming Song, Johannes Bjelland, Brian Uzzi, Dashun Wang   +5 more
wiley   +1 more source

Mobile Objects and Agents (MOA) [PDF]

Distributed Systems Engineering, 1998
This paper describes the design and implementation of the Mobile Objects and Agents (MOA) project at the Open Group Research Institute. MOA was designed to support migration, communication and control of agents. It was implemented on top of the Java Virtual Machine, without any modifications to it.
Dejan S. Milojicic, William LaForge, Deepika Chauhan   +2 more
openaire   +3 more sources

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

La escultura ambiental y monumentaria de Moa

, 2012
LibroDesde su origen, la escultura ha sido esencial para el desarrollo cultural del municipio de Moa y ocupa un lugar sustancial en la fisonomía de la ciudad, aunque poco reconocido en el desarrollo histórico de la región.
Carralero Rodríguez, Susana
core   +1 more source

Update: Mode of action (MOA) for liver tumors induced by oral exposure to 1,4‐dioxane

Regulatory toxicology and pharmacology : RTP, 2017
Previous work has shown that the weight of evidence supports the hypothesis that 1,4‐dioxane causes liver tumors in rodents through cytotoxicity and subsequent regenerative hyperplasia.
M. Dourson, J. Higginbotham, Jeff Crum, H. Burleigh-Flayer, P. Nance, Norman D Forsberg, M. Lafranconi, J. Reichard   +7 more
semanticscholar   +1 more source

Soft-tissue specimens from pre-European extinct birds of New Zealand [PDF]

, 2012
We provide the first complete review of soft tissue remains from New Zealand birds that became extinct prior to European settlement (c. AD 1800). These rare specimens allow insights into the anatomy and appearance of the birds that are not attainable ...
Scofield, R. P., Wood, Jamie R., Rawlence, Nicolas J., Fraser, C, Tennyson, A. J. D.   +4 more
core   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source