Results 51 to 60 of about 126,389 (308)

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Beyond the abstract—concrete dichotomy: Mode of acquisition, concreteness, imageability, familiarity, age of acquisition, context availability, and abstractness norms for a set of 417 Italian words [PDF]

, 2018
The main objective of this study is to investigate the abstract-concrete dichotomy by introducing a new variable: the mode of acquisition (MoA) of a concept.
Cappa, Stefano, Catricalà, Eleonora, Della Rosa, Pasquale, Vigliocco, Gabriella   +3 more
core  

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Possible Solution of the long-standing discrepancy in the Microlensing Optical Depth Toward the Galactic Bulge by correcting the stellar number count [PDF]

, 2016
We find that significant incompleteness in stellar number counts results in a significant overestimate of the microlensing optical depth $\tau$ and event rate per star per year $\Gamma$ toward the Galactic bulge from the first two years of the MOA-II ...
Penny, M. T., Sumi, T.
core   +3 more sources

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

OGLE-2009-BLG-092/MOA-2009-BLG-137: A Dramatic Repeating Event With the Second Perturbation Predicted by Real-Time Analysis [PDF]

, 2010
We report the result of the analysis of a dramatic repeating gravitational microlensing event OGLE-2009-BLG-092/MOA-2009-BLG-137, for which the light curve is characterized by two distinct peaks with perturbations near both peaks.
A. Allan, A. Cassan, A. Cole, A. Fukui, A. Gal-Yam, A. Gould, A. Korpela, A. Shporer, A. Udalski, Albrow, B. Monard, B. S. Gaudi, Bennett, Bennett, C. H. Ling, C. Han, C. Liebig, C. S. Botzler, C. Snodgrass, C.-U. Lee, Ch. Coutures, D. J. Sullivan, D. L. Depoy, D. M. Bramich, D. Maoz, D. Moorhouse, D. P. Bennett, D. Polishook, D. Ricci, D. Suzuki, Dominik, Dominik, Dominik, Dong, Dong, E. Corrales, Erdl, F. Abe, F. Finet, F. Grundahl, F. Hayashi, F. V. Hessman, F. Zimmer, G. Maier, G. Pietrzyński, G. Scarpetta, G. Thornley, G. W. Christie, Gould, Gould, Han, Han, I. A. Bond, I. Soszyński, I. Steele, J. B. Hearnshaw, J. C. Yee, J. Greenhill, J. McCormick, J. Menzies, J. Skottfelt, J. Southworth, J. Surdej, J. Wambsganss, J.-P. Beaulieu, Jaroszyński, K. Furusawa, K. Harpsøe, K. Horne, K. Kamiya, K. Masuda, K. Nishimoto, K. Ohnishi, K. Ulaczyk, K. Wada, K.-H. Hwang, L. Mancini, L. Skuljan, M. Bos, M. D. Albrow, M. Dominik, M. Glitrup, M. Hundertmark, M. J. Burgdorf, M. K. Szymański, M. Kubiak, M. Mathiasen, N. Kains, N. Miyake, N. Rattenbury, O. Szewczyk, P. Browne, P. C. M. Yock, P. Fouqué, P. J. Tristram, P. M. Kilmartin, Pejcha, R. Poleski, R. Street, R. W. Pogge, Refsdal, S. Brillant, S. Calchi Novati, S. Dieters, S. Dreizler, S. Hosaka, S. Kaspi, S. Makita, S. Rahvar, Schneider, Sumi, T. C. Hinse, T. Sumi, To. Saito, U. G. Jørgensen, Udalski, V. Batista, V. Bozza, W. L. Sweatman, W. Lin, Y. C. Perrott, Y. Itow, Y. Matsubara, Y. Muraki, Y. Shvartzvald, Y. Tsapras, Y.-H. Ryu, Yee, Yoo, Ł. Wyrzykowski   +129 more
core   +3 more sources

Impact of Agitation Power Input on Aspergillus oryzae Metabolism: Application of Multi‐Omics on an Industrial Enzyme Fermentation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino, Jean‐Marie Mouillon, Gisela Nadal‐Rey, Carina L. Gargalo, Ulrich Krühne, Krist V. Gernaey, Mads O. Albæk   +6 more
wiley   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

MAQUETAS DE ARTICULACIONES COXOFEMORAL Y ESCAPULOHUMERAL COMO MATERIAL DIDÁCTICO PARA LA ENSEÑANZA DE ANATOMÍA HUMANA A ESTUDIANTES DE CIENCIAS MÉDICAS

Revista de Innovación Social y Desarrollo, 2023
Se diseñó un material didáctico, como herramienta tecnológica para la enseñanza de anatomía humana en estudiantes de la Filial de Ciencias Médicas «Tamara Bunke Bider» del municipio Moa. La investigación realizada es didáctica.
Yaima Barzaga Galano, Daiyana Suarez Arcia, Nury Cervantes Hinojosa, Diana Yadira Gonzales Sánchez, Nuvia Gisela Ramírez Romero   +4 more
doaj  

Planetary and Other Short Binary Microlensing Events from the MOA Short Event Analysis

, 2012
We present the analysis of four candidate short duration binary microlensing events from the 2006-2007 MOA Project short event analysis. These events were discovered as a byproduct of an analysis designed to find short timescale single lens events that ...
A. Fukui, A. V. Korpela, Alard, Alard, Alcock, Alcock, Bennett, Bennett, Bennett, Bennett, Bennett, Bennett, Bennett, Bond, Bonfils, Borucki, Boss, Bowler, Butler, C. H. Ling, C. S. Botzler, Chang, D'Angelo, D. J. Sullivan, D. P. Bennett, D. Suzuki, Di Stefano, Di Stefano, Dong, F. Abe, Ford, Gaudi, Gould, Gould, Gould, Guillochon, Han, Han, Hilton, Hilton, Holman, Holtzman, I. A. Bond, Ida, Janczak, Johnson, K. Furusawa, K. Kamiya, K. Masuda, K. Ohnishi, K. Wada, Kennedy, Kennedy, Kowalski, Kowalski, Laughlin, Lecar, Levison, Muraki, N. J. Rattenbury, N. Miyake, Nagasawa, P. C. M. Yock, P. J. Tristram, P. M. Kilmartin, Pejcha, Pietrukowicz, Popowski, Sumi, Szymański, T. Sumi, To. Saito, Udalski, Udalski, Udalski, Udalski, Udalski, W. L. Sweatman, Y. Itow, Y. Matsubara, Y. Muraki   +80 more
core   +1 more source