Results 71 to 80 of about 138,791 (334)

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Self-Sorting Microscale Compartmentalized Block Copolypeptide Hydrogels [PDF]

, 2019
Multicomponent interpenetrating network hydrogels possessing enhanced mechanical stiffness compared to their individual components were prepared via physical mixing of diblock copolypeptides that assemble by either hydrophobic association or polyion ...
Bentolila, Laurent A, Deming, Timothy J, Sun, Yintao   +2 more
core  

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, EarlyView.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source

Caractérisation des matières organiques anthropiques pour comprendre et prédire leurs dynamiques et leurs effets après apport au sol [PDF]

, 2006
Les activités anthropiques produisent des masses importantes de déchets organiques dont le retour au sol, sous réserve de leur innocuité, constitue une alternative à leur incinération ou leur mise en décharge.
Dignac, M.F., Francou, C., Houot, Sabine, Parnaudeau, Virginie, Thuriès, Laurent   +4 more
core  

Do Corporate Strategies in Fintech and Green Finance Enhance ESG Performance? The Moderating Role of Government Policies

Business Strategy and the Environment, EarlyView.
ABSTRACT Despite the growing interest in ESG performance, limited research explores the mediating role of government policy in the relationship between Fintech, green finance and ESG outcomes. We address this gap by examining how Fintech and green finance influence ESG performance through government policies.
Mandella Osei‐Assibey Bonsu, Samuel Clottey Attuquaye, Katie Hyslop, Ying Wang, Li Kaodui   +4 more
wiley   +1 more source

Does Sustainability Auditing Lead to Enhanced Corporate Governance, Environmental Performance, and Financial Outcomes? Empirical Evidence From High‐Impact Industries

Business Strategy and the Environment, EarlyView.
ABSTRACT This study employs hierarchical regression modelling on a survey of 550 firms from Nigeria and Ghana to examine the impact of sustainability auditing on corporate governance, environmental performance, and financial outcomes of high‐impact industries.
Mandella Osei‐Assibey Bonsu, Ying Wang, Grace Eghe‐Ikhurhe, Katie Hyslop   +3 more
wiley   +1 more source

NREM Sleep Instability in Pediatric Migraine Without Aura

Frontiers in Neurology, 2019
Children with migraine headaches appear to have a range of sleep disturbances. The aim of the present study was to assess the NREM sleep instability in a population of school-aged individuals affected by migraine without aura (MoA). Thirty-three children
Michele Roccella, Rosa Marotta, Francesca Felicia Operto, Daniela Smirni, Francesco Precenzano, Ilaria Bitetti, Giovanni Messina, Francesco Sessa, Giulio Di Mizio, Carla Loreto, Monica Salerno, Vincenzo Russo, Paolo Murabito, Beatrice Gallai, Maria Esposito, Diego Iacono, Diego Iacono, Diego Iacono, Marco Carotenuto   +18 more
doaj   +1 more source

The Extreme Microlensing Event OGLE-2007-BLG-224: Terrestrial Parallax Observation of a Thick-Disk Brown Dwarf [PDF]

, 2009
Parallax is the most fundamental technique to measure distances to astronomical objects. Although terrestrial parallax was pioneered over 2000 years ago by Hipparchus (ca.
A. Allan, A. Fukui, A. Gould, A. Korpela, A. Udalski, A. Williams, Alves, An, B. Monard, B. S. Gaudi, B.-G. Park, Bennett, Burgasser, Burgasser, Burgasser, Burrows, C. Coutures, C. H. Ling, C. Han, C. Mottram, C. S. Botzler, C. Snodgrass, C.-U. Lee, D. J. Sullivan, D. L. DePoy, D. M. Bramich, D. P. Bennett, Dong, Dong, E. Kerins, F. Abe, Faherty, Fukui, G. Pietrzyński, G. W. Christie, Gaudi, Gould, Gould, Gould, Gould, Gould, Gould, Gould, H. Calitz, Han, Hardy, Hipparchus of Nicaea, Holz, I. A. Bond, I. A. Steele, I. Soszyński, J. B. Hearnshaw, J. Caldwell, J. McCormick, J. P. Beaulieu, Jaroszynski, K. Furusawa, K. Horne, K. Kamiya, K. Masuda, K. Ohnishi, K. Sahu, K. Ulaczyk, L. Skuljan, M. Albrow, M. Dominik, M. F. Bode, M. J. Burgdorf, M. K. Szymański, M. Kubiak, M. Nagaya, Metchev, N. Miyake, N. Rattenbury, O. Szewczyk, P. C. M. Yock, P. Fouque, P. J. Tristram, P. M. Kilmartin, Poindexter, R. Martin, R. Street, R. W. Pogge, S. N. Fraser, Skruttskie, Snodgrass, Subo Dong, T. Natusch, T. Okumura, T. Sako, T. Sumi, To. Saito, Udalski, Udalski, W. Allen, W. L. Sweatman, W. Lin, Y. C. Perrott, Y. Itow, Y. Matsubara, Y. Muraki, Y. Tsapras, Yoo, Ł. Wyrzykowski   +103 more
core   +5 more sources

MOA-2011-BLG-262Lb: A SUB-EARTH-MASS MOON ORBITING A GAS GIANT PRIMARY OR A HIGH VELOCITY PLANETARY SYSTEM IN THE GALACTIC BULGE [PDF]

, 2013
We present the first microlensing candidate for a free-floating exoplanet–exomoon system, MOA-2011-BLG-262, with a primary lens mass of Mhost ∼ 4 Jupiter masses hosting a sub-Earth mass moon.
D. P. Bennett, V. Batista, I. Bond, C. S. Bennett, D. Suzuki, J. Beaulieu, A. Udalski, J. Donatowicz, V. Bozza, V. Bozza, F. Abe, C. Botzler, M. Freeman, D. Fukunaga, A. Fukui, Y. Itow, N. Koshimoto, C. Ling, K. Masuda, Y. Matsubara, Yasushi Muraki, S. Namba, K. Ohnishi, N. Rattenbury, T. Saito, D. Sullivan, T. Sumi, W. Sweatman, P. Tristram, N. Tsurumi, K. Wada, P. Yock, M. Albrow, É. Bachelet, S. Brillant, J. Caldwell, A. Cassan, A. Cole, E. Corrales, C. Coutures, S. Dieters, D. Prester, P. Fouqué, J. Greenhill, K. Horne, J. Koo, D. Kubas, J. Marquette, R. Martin, J. Menzies, K. Sahu, J. Wambsganss, A. Williams, M. Zub, J.-Y. Choi, D. DePoy, S. Dong, B. Gaudi, A. Gould, C. Han, Calen Henderson, D. McGregor, C.‐U. Lee, R. Pogge, I. Shin, J. Yee, J. Yee, M. Szymański, J. Skowron, R. Poleski, R. Poleski, S. Kozllowski, L. Wyrzykowski, M. Kubiak, P. Pietrukowicz, G. Pietrzyński, G. Pietrzyński, I. Soszyński, K. Ulaczyk, Y. Tsapras, Y. Tsapras, R. Street, M. Dominik, M. Dominik, D. Bramich, P. Browne, M. Hundertmark, N. Kains, C. Snodgrass, I. Steele, I. Dékány, O. Gonzalez, D. Heyrovský, R. Kandori, E. Kerins, P. Lucas, D. Minniti, T. Nagayama, M. Rejkuba, A. Robin, R. Saito   +100 more
semanticscholar   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source