Results 51 to 60 of about 5,770,238 (330)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Resilience of multi-robot systems to physical masquerade attacks [PDF]
, 2019 The advent of autonomous mobile multi-robot systems has driven innovation in both the industrial and defense sectors. The integration of such systems in safety-and security-critical applications has raised concern over their resilience to attack. In this
Li, Wenchao +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Age Optimal Information Gathering and Dissemination on Graphs
, 2019 We consider the problem of timely exchange of updates between a central station and a set of ground terminals $V$, via a mobile agent that traverses across the ground terminals along a mobility graph $G = (V, E)$.
Modiano, Eytan +2 more
core +1 more source
A multi-agent system to support location based group decision making in mobile teams [PDF]
, 2003 This paper describes an agent-based approach for developing a location-based asynchronous group decision-support system for mobile teams. The approach maximises the use of reusable service components (GSCmas — generic service component for multi-agent ...
Buckland, MA, Lee, H, Shepherdson, JW
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Robust Decentralized Abstractions for Multiple Mobile Manipulators
, 2017 This paper addresses the problem of decentralized abstractions for multiple mobile manipulators with 2nd order dynamics. In particular, we propose decentralized controllers for the navigation of each agent among predefined regions of interest in the ...
Dimarogonas, Dimos V. +1 more
core +1 more source
Mobile Agents for Mobile Users [PDF]
, 2000 In this paper we propose the use of mobile agents in the implementation of mobility support. The paper starts with a presentation of the mobile agent concept. Then, the notion of ideal user mobility is presented and followed by the current mobility support approaches.
Do van Thanh +2 more
openaire +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source