Results 91 to 100 of about 389,080 (344)

Horizontal DNA transfer mechanisms of bacteria as weapons of intragenomic conflict [PDF]

, 2016
Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial species, but its primary evolutionary role remains controversial.
A Adams, A Adams, AB Dalia, AI Khan, B Martin, BJ Haijema, BR Levin, C Boutry, C Buchrieser, C Camacho, C Canchaya, C Chewapreecha, C Fraser, C Johnston, C Johnston, C Johnston, Christophe Fraser, Christopher Wymant, CS Wylie, D Dubnau, D Hyatt, DA Baltrus, DA Caugant, DA Higgins, DA Morrison, DA Morrison, DE Fouts, DJP Engelmoer, E Borezee, E Szathmáry, E V Pestova, E Zaccaria, EA Campbell, EJ Feil, EJ Gaasbeek, EJ Gaasbeek, EP Rocha, ES Antonova, F Ginetti, F Griffith, F Liu, GG Wilson, GJ Stewart, GM Süel, GW Goldberg, H Bagci, H Bernstein, H Deveau, H Li, H Maamar, H Muller, H Ochman, H Tong, H-H Chou, HC Neu, I Chen, I Mortier-Barriere, I Mortier-Barrière, J Bondy-Denomy, J Guglielmini, J Majewski, J Majewski, J-P Claverys, JA Lanie, JA Londoño-Vallejo, JA Mongold, JC Lefevre, JC Mell, JH Stuy, JJ Sakamoto, JK Setlow, JM Auchtung, JM Musser, JM Smith, JM Smith, JO McInerney, JP Claverys, JP Claverys, JT Simpson, JW Beaber, K Turgay, KS Makarova, KT Konstantinidis, L Attaiech, L Fontaine, L Van Valen, L-M Bobay, LP Macfadyen, LS Frost, LS Håvarstein, LS Håvarstein, M Berge, M Boetzer, M Del Grosso, M Prudhomme, M Ramirez, MA Hoelzer, ME Kahn, MF Wojciechowski, MJ Lopez-Sanchez, ML Gwinn, MR Oggioni, MS Dorer, MTG Holden, Nicholas J. Croucher, Nick H. Barton, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, O Johnsborg, OE Cornejo, OH Ambur, OT Avery, P Glaser, P Jorth, P Luo, PA Levin, Paul Turner, PJ Johnsen, R Davidoff-Abelson, R Edgar, R Mostowy, RA Fisher, Rafal Mostowy, RE Michod, RE Yasbin, RJ Redfield, RJ Redfield, RJ Redfield, RJ Redfield, RJ Redfield, RJ Redfield, RK Aziz, RP Novick, S Lacks, SA McMahon, SB Beres, SE Finkel, SJ Labrie, SP Otto, Stephen D. Bentley, T Carver, T Nozawa, U Munoz-Najar, WA Sweetman, WJ Kent, X Charpentier, X Charpentier, X Didelot, Y Li, Z Zhou   +157 more
core   +3 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Suspended Materials in River Waters Differentially Enrich Class 1 Integron- and IncP-1 Plasmid-Carrying Bacteria in Sediments

Frontiers in Microbiology, 2018
Aquatic ecosystems are frequently considered as the final receiving environments of anthropogenic pollutants such as pharmaceutical residues or antibiotic resistant bacteria, and as a consequence tend to form reservoirs of antibiotic resistance genes ...
Magali De la Cruz Barrón, Christophe Merlin, Hélène Guilloteau, Emmanuelle Montargès-Pelletier, Emmanuelle Montargès-Pelletier, Xavier Bellanger   +5 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Detection of mobile genetic elements in multidrug-resistant Klebsiella pneumoniae isolated from different infection sites in Hamadan, west of Iran

BMC Research Notes, 2021
Objective Klebsiella pneumoniae is one of most opportunistic pathogens that can be related to nosocomial infections. Increased acquisitions of multidrug resistance in this bacterium as well as the transfer of genes to other strains have caused concern ...
Babak Asghari, Rezvan Goodarzi, Milad Mohammadi, Fatemeh Nouri, Mohammad Taheri   +4 more
doaj   +1 more source

How the other half lives: CRISPR-Cas's influence on bacteriophages

, 2017
CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers.
AE Briner, AF Andersson, BR Levin, C Pourcel, CL Sun, D Bhaya, E Pennisi, E Scarpellini, EV Koonin, FS Berezovskaya, GW Tyson, H Deveau, H Deveau, I Yosef, IN Berezovsky, J He, J Iranzo, J Mahony, JF Heidelberg, JM Peters, JO Haerter, KD Seed, KL Maxwell, LA Marraffini, LM Childs, M Sebaihia, P Han, P Horvath, P Horvath, PD Hsu, R Barrangou, R Lillestøl, R Sorek, S Al-Attar, S Minot, W Jiang   +35 more
core   +1 more source

Neutral genomic microevolution of a recently emerged pathogen, salmonella enterica serovar agona [PDF]

, 2013
Salmonella enterica serovar Agona has caused multiple food-borne outbreaks of gastroenteritis since it was first isolated in 1952. We analyzed the genomes of 73 isolates from global sources, comparing five distinct outbreaks with sporadic infections as
Achtman, Mark, Brisse, Sylvain, Brown, Derek, Cormican, Martin, Fanning, Seamus, Guttman, David S., Litrup, Eva, McCann, Angela, Murphy, Ronan, Zhou, Zhemin   +9 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity [PDF]

, 2004
We report the transcriptional response of Escherichia coli MG1655 to damage induced by colicins E3 and E9, bacteriocins that kill cells through inactivation of the ribosome and degradation of chromosomal DNA, respectively. Colicin E9 strongly induced the
Hinton, Jay C. D., James, Richard, Kleanthous, Colin, Moore, Geoffrey R., Rolfe, Matthew, Thompson, Arthur, WALKER, DANIEL   +6 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source