Results 111 to 120 of about 86,970 (297)

Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer

, 2018
The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons ...
Jose Luis Garcia Perez, Tammy A. Morrish
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Correction: Mammalian Small Nucleolar RNAs Are Mobile Genetic Elements. [PDF]

PLoS Genetics, 2007
Michel J Weber
doaj   +3 more sources

Chromosomal location of retrotransposable REX 1 in the genomes in five Prochilodus (Teleostei: Characiformes)

, 2013
Transposable elements are repetitive DNA sequences comprising a group of segments able to move and carry sequences within the genome. Studies involving comparative genomics have revealed that most vertebrates have different populations of transposable ...
Voltolin, Tatiana Aparecida, Mendonça, Bruna Bueno, Porto-Foresti, Fábio, Voltolin, Tatiana Aparecida [UNESP], Ferreira, Daniela Cristina, Senhorini, José Augusto, Foresti, Fausto   +6 more
core   +1 more source

Pathogenomics of mobile genetic elements of toxigenic bacteria

International Journal of Medical Microbiology, 2004
The growing knowledge of genetic diversity and whole genome organization in bacteria shows that pathogenicity islands (PAIs) represent a subtype of a more general genetic element, termed genomic island (GEI), which is widespread among pathogenic and non-pathogenic microbes.
Jörg, Hacker, Bianca, Hochhut, Barbara, Middendorf, György, Schneider, Carmen, Buchrieser, Gerhard, Gottschalk, Ulrich, Dobrindt   +6 more
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Mobile genetic elements associated with antimicrobial resistance

, 2018
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an increasing major health care problem around the world.
Jensen, Slade O. (R16034), Firth, Neville, Kwong, Stephen M. (R20881), Partridge, Sally R.   +3 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Evolutionary History of Bacteriophages in the Genus Paraburkholderia

Frontiers in Microbiology, 2018
The genus Paraburkholderia encompasses mostly environmental isolates with diverse predicted lifestyles. Genome analyses have shown that bacteriophages form a considerable portion of some Paraburkholderia genomes.
Akbar Adjie Pratama, Maryam Chaib De Mares, Jan Dirk van Elsas   +2 more
doaj   +1 more source