Results 71 to 80 of about 410,012 (337)

Some problems and errors in cytogenetic biodosimetry [PDF]

, 2016
Human radiosensitivity is a quantitative trait that is generally subject to binomial distribution. Individual radiosensitivity, however, may deviate significantly from the mean (by 2-3 standard deviations).
Kilchevsky, Alexander, Mosse, Irma, Nikolova, Nevena, Zhelev, Nikolai   +3 more
core   +5 more sources

Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes

Nature Microbiology
The exchange of mobile genetic elements (MGEs) facilitates the spread of functional traits including antimicrobial resistance within bacterial communities.
Benjamin Grodner, Hao Shi, Owen Farchione, A. Vill, Ioannis Ntekas, Peter Diebold, David T. Wu, Chia-Yu Chen, David M. Kim, Warren R. Zipfel, I. Brito, Iwijn De Vlaminck   +11 more
semanticscholar   +1 more source

Recruitment of Mobile Genetic Elements for Diverse Cellular Functions in Prokaryotes

Frontiers in Molecular Biosciences, 2022
Prokaryotic genomes are replete with mobile genetic elements (MGE) that span a continuum of replication autonomy. On numerous occasions during microbial evolution, diverse MGE lose their autonomy altogether but, rather than being quickly purged from the ...
Sean Benler, E. Koonin
semanticscholar   +1 more source

Transposable Elements, Inflammation, and Neurological Disease. [PDF]

, 2019
Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela, Muotri, Alysson R, Saleh, Aurian   +2 more
core  

Genomic insights into the rapid emergence and evolution of MDR in Staphylococcus pseudintermedius. [PDF]

, 2014
OBJECTIVES: MDR methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains have emerged rapidly as major canine pathogens and present serious treatment issues and concerns to public health due to their, albeit low, zoonotic potential. A further
A. J. McCarthy, A. Loeffler, A. Waller, B. Leggett, Bannoehr, Besier, Black, Bond, Croucher, D. H. Lloyd, Darling, De Lucia, E. M. Harrison, Feil, Feng, Geoghegan, Gortel, J. A. Lindsay, K. Stanczak-Mrozek, Kadlec, Koser, Loeffler, Loeffler, M. A. Holmes, Magiorakos, Noguchi, Prescott, Quail, Roberts, Ruscher, Rutherford, Soedarmanto   +31 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Interaction of Antibiotics and Humic Substances: Environmental Consequences and Remediation Prospects

Molecules, 2022
The occurrence and distribution of antibiotics in the environment has received increasing attention due to their potential adverse effects on human health and ecosystems.
Natalia A. Kulikova, Alexandra A. Solovyova, Irina V. Perminova   +2 more
doaj   +1 more source

Metagenomic assembly is the main bottleneck in the identification of mobile genetic elements

PeerJ
Antimicrobial resistance genes (ARG) are commonly found on acquired mobile genetic elements (MGEs) such as plasmids or transposons. Understanding the spread of resistance genes associated with mobile elements (mARGs) across different hosts and ...
Jesse J. Kerkvliet, Alex Bossers, J. G. Kers, Rodrigo Meneses, R. Willems, A. Schürch   +5 more
semanticscholar   +1 more source

Mobile Genetic Elements Drive Antimicrobial Resistance Gene Spread in Pasteurellaceae Species

Frontiers in Microbiology, 2022
Mobile genetic elements (MGEs) and antimicrobial resistance (AMR) drive important ecological relationships in microbial communities and pathogen-host interaction.
G. C. da Silva, O. S. Gonçalves, J. Rosa, Kiara Campos França, J. Bossé, M. Santana, P. Langford, D. Bazzolli   +7 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source