Results 51 to 60 of about 6,093,234 (295)

Pathological and Evolutionary Implications of Retroviruses as Mobile Genetic Elements

, 2013
Retroviruses, a form of mobile genetic elements, have important roles in disease and primate evolution. Exogenous retroviruses, such as human immunodeficiency virus (HIV), have significant pathological implications that have created a massive public ...
Mackenzie Whitesell, Madeline Hayes, Mark Brown   +2 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Comparative genomics reveals differences in mobile virulence genes of Escherichia coli O103 pathotypes of bovine fecal origin. [PDF]

PLoS ONE, 2018
Escherichia coli O103, harbored in the hindgut and shed in the feces of cattle, can be enterohemorrhagic (EHEC), enteropathogenic (EPEC), or putative non-pathotype.
Lance W Noll, Jay N Worley, Xun Yang, Pragathi B Shridhar, Justin B Ludwig, Xiaorong Shi, Jianfa Bai, Doina Caragea, Jianghong Meng, T G Nagaraja   +9 more
doaj   +1 more source

Transposable elements as a potential source for understanding the fish genome

, 2011
Transposable elements are repetitive sequences with the capacity to move inside of the genome. They constitute the majority of the eukaryotic genomes, and are extensively present in the human genome, representing more than 45% of the genome sequences ...
Porto-Foresti, Fábio [UNESP], Oliveira, Claudio de [UNESP], Daniela Cristina Ferreira, Foresti, Fausto [UNESP], Fausto Foresti, Porto-Foresti, Fábio, Claudio Oliveira, Ferreira, Daniela Cristina [UNESP], Fabio Porto-Foresti, Ferreira, Daniela Cristina, Oliveira, Claudio de, Foresti, Fausto   +11 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Investigation into the mobile genetic elements of Clostridium difficile [PDF]

, 2013
Clostridium difficile is a pathogenic bacterium that can colonise both humans and various animals. Toxin production leads to clinical symptoms ranging from mild to severe diarrhoea and can result in potentially fatal pseudomembranous colitis.
Brouwer, MSM
core  

Mobilizable genomic islands, different strategies for the dissemination of multidrug resistance and other adaptive traits

, 2017
Mobile genetic elements are near ubiquitous DNA segments that revealed a surprising variety of strategies for their propagation among prokaryotes and between eukaryotes.
Vincent Burrus, Rivard, N., Carraro, N., Ceccarelli, D., Ceccarelli, Daniela, Nicolas Carraro, Daniela Ceccarelli, Burrus, V., Nicolas Rivard   +8 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Distribution and Implications of Haloarchaeal Plasmids Disseminated in Self-Encoded Plasmid Vesicles

Microorganisms, 2023
Even though viruses and plasmids are both drivers of horizontal gene transfer, they differ fundamentally in their mode of transfer. Virus genomes are enclosed in virus capsids and are not dependent on cell-to-cell contacts for their dissemination.
Dominik Lücking, Tomás Alarcón-Schumacher, Susanne Erdmann   +2 more
doaj   +1 more source

Social Diversification Driven by Mobile Genetic Elements

Genes, 2023
Social diversification in microbes is an evolutionary process where lineages bifurcate into distinct populations that cooperate with themselves but not with other groups. In bacteria, this is frequently driven by horizontal transfer of mobile genetic elements (MGEs). Here, the resulting acquisition of new genes changes the recipient’s social traits and
Michael L. Weltzer, Daniel Wall
openaire   +2 more sources