Results 81 to 90 of about 3,141,117 (304)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Getting Ahead or Losing Ground: Economic Mobility in America [PDF]
, 2008 Combines earlier research to present a comprehensive analysis of relative mobility, absolute mobility, and changes in income inequality.
Isabel V. Sawhill +2 more
core
Coupling Human Mobility and Social Ties [PDF]
, 2014 Studies using massive, passively data collected from communication technologies have revealed many ubiquitous aspects of social networks, helping us understand and model social media, information diffusion, and organizational dynamics.
Gonzalez, Marta C. +3 more
core +2 more sources
What’s mobile in mobile communication? [PDF]
Mobile Media & Communication, 2013 Interrogating the terminology of “mobile” communication, this article notes that media and communicative practices have been mobile for millennia. What’s mobile about cell phones and other current mobile media is a new range of contexts in which personally meaningful and socially consequential interactions become possible.
openaire +3 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
BMC Research Notes, 2021 Objective Many economically developed countries have seen a decline in publicly funded community programming. Within this context, community-based seniors’ service (CBSS) organizations have been increasingly tasked to deliver programs to support the ...
Catherine E. Tong +3 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Tariffs on electric vehicles deepen woes of U.S. electrification stagnation
npj Climate ActionDespite the U.S. climate ambitions requiring a 24% annual growth in EV sales, its EV market has experienced slow growth. Affordable EV imports could help break this stagnation, but the U.S. imposed high tariffs, to protect domestic auto industry.
Ming Liu +8 more
doaj +1 more source
International Journal of Transportation Science and TechnologyDue to the increasing demand for goods movement, externalities from freight mobility have attracted much concern among local citizens and policymakers.
Quan Yuan +3 more
doaj +1 more source
On the road: travelling salesmen and experiences of mobility in Britain before 1939 [PDF]
, 2010 Mobility has been a significant influence in the formation of identities for individuals and for certain occupations. Recent studies emphasises the associations of mobility with a sense of autonomy and personal freedom.
French, M.
core +1 more source