Results 71 to 80 of about 1,736,908 (306)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Collaborative Mobile-To-Mobile Computation Offloading [PDF]
Proceedings of the 10th IEEE International Conference on Collaborative Computing: Networking, Applications and Worksharing, 2014 It is common practice for mobile devices to offload computationally heavy tasks off to a cloud, which has greater computational resources. In this paper, we consider an environment in which computational offloading is made among collaborative mobile devices.We call such an environment a mobile device cloud (MDC).
Abderrahmen Mtibaa +4 more
openaire +3 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Globalizations, 2019 This article considers how an increasingly visible set of mobilities has implications for how peace and conflict are imagined and responded to. We are particularly interested in how these mobilities take form in everyday actions and shape new forms of peace and challenge existing ones.
Richmond, Oliver P., Mac Ginty, Roger
openaire +4 more sources
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Wage Mobility Through Job Mobility [PDF]
The purpose of this paper is to study the relationship between job mobility and wage mobility. One of the main points of this paper is that job mobility is not necessarily bad.
Marcela C. Perticara(Georgetown University/Ilades)
core +4 more sources
Tariffs on electric vehicles deepen woes of U.S. electrification stagnation
npj Climate ActionDespite the U.S. climate ambitions requiring a 24% annual growth in EV sales, its EV market has experienced slow growth. Affordable EV imports could help break this stagnation, but the U.S. imposed high tariffs, to protect domestic auto industry.
Ming Liu +8 more
doaj +1 more source