Results 71 to 80 of about 9,402,447 (340)
Pediatric Critical Care Medicine, 2022 Supplemental Digital Content is available in the text. RATIONALE: A guideline that both evaluates current practice and provides recommendations to address sedation, pain, and delirium management with regard for neuromuscular blockade and withdrawal is ...
Heidi A. B. Smith +28 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Generic Models for Mobility Management in Next Generation Networks [PDF]
, 2005 In the network community different mobility management techniques have been proposed over the years. However, many of these techniques share a surprisingly high number of similarities.
Cristofano, Maria Luisa +2 more
core +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Joint Deployment and Mobility Management of Energy Harvesting Small Cells in Heterogeneous Networks
IEEE Access, 2017 Small heterogeneous cells have been introduced to improve the system capacity and provide the ubiquitous service requirements. In order to make flexible deployment and management of massive small cells, the utilization of self-powered small cell base ...
Guanhua Qiao +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A Mobility-Oriented Scheme for Virtual Machine Migration in Cloud Data Center Network
IEEE Access, 2016 Being a key computing element in cloud data center, virtual machines should be able to migrate from one location to another to meet the requirements of the cloud users and the defined policies of the cloud computing system.
Bo Hu +3 more
doaj +1 more source
Innovations in Shared Mobility—Review of Scientific Works
Smart Cities, 2023 Shared mobility is developing at a very fast pace around the world, becoming an alternative to classic forms of travel and, according to the public, providing innovative services.
Katarzyna Turoń, János Tóth
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Mobility-Based Cell and Resource Allocation for Heterogeneous Ultra-Dense Cellular Networks
IEEE Access, 2018 Heterogeneous ultra-dense network (HUDN) is a promising network structure, which increases network efficiency in 4G and 5G networks. However, it faces the new challenges regarding interference and mobility management.
Masoud Farokhi +2 more
doaj +1 more source