Results 111 to 120 of about 1,520,948 (343)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Sound Radiation Analysis and Noise Reduction Design of Railway Wheel

机车电传动, 2018
The wheel radiation noise is an important contributor of railway noise. Based on the acoustic simulation and experimental techniques, this paper analyzed the radiation noise characteristics of a wheel, and designed a noise reduction wheel combined with ...
ZHA Guotao, FU Rong, FU Liang, TU Fengchen, HE Caichun   +4 more
doaj  

Comparative Property Analysis of One-by-One Rib Lingerie Fabrics Fabricated from Modal Fibers and Microfibers

Nanomaterials
Although the applicability of modal fibers and microfibers for the production of lingerie knitwear is confirmed by commercial use, their share in the total consumption of man-made cellulosic fibers is very low.
Antoneta Tomljenović, Juro Živičnjak
doaj   +1 more source

SISA LEBIH PEMBIAYAAN ANGGARAN DAN DESENTRALISASI FISKAL TERHADAP BELANJA MODAL PEMERINTAH DAERAH KABUPATEN/KOTA DI JAWA BARAT

, 2021
Neni Nurhayati
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Design of Axle Gear Case in Tunnel Traction Locomotive Based on Rigid-flexible Coupling Model by Using Romax

机车电传动, 2017
The rigid-flexible coupling model of axle gear case in tunnel traction locomotive which included the flexible axle and case body was established using Romax, Inventor and Hypermesh software.
LIAN Zhenhong, YANG Zhonglei
doaj  

Research on mechanism of resilient wheel sluggish movement and discussion on relevant solution

机车电传动, 2022
Resilient wheels can effectively reduce the transmission of high frequency vibration and impact between wheel and rail, and reduce wheel/rail noise, so they are widely used in tramcars.
SHI Lu, HU Huoli, LI Wen, WANG Wenhua, QI Yuan, LI Nuo   +5 more
doaj  

Relasi Intelektual, Modal, dan Negara di Indonesia: Faktor-faktor Yang Mengkondisikan dan Implikasinya

Jurnal Politik, 2017
Dalam pengalaman relasi intelektual, modal dan negara pada era Reformasi, terdapat dua faktor yang mempengaruhi bagaimana relasi tersebut terbentuk. Secara struktural, faktor pertama ialah dorongan pencarian legitimasi politik oleh negara dan faktor ...
Muhammad Fajar
doaj   +1 more source

Nonparametric and Varying Coefficient Modal Regression

, 2016
In this article, we propose a new nonparametric data analysis tool, which we call nonparametric modal regression, to investigate the relationship among interested variables based on estimating the mode of the conditional density of a response variable Y ...
Xiang, Sijia, Yao, Weixin
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source