Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Journal of Logic and Computation, 2004 The paper is devoted to an investigation of properties of dynamic modal logics with some interesting and rich features. A dynamic modal logic DML and its extension \(\mu\)DML are presented. They were developed in order to unify and extend dynamic epistemic logics proposed before in another paper by the author.
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Diagnostic value of risk malignancy index in the preoperative evaluation of ovarian mass correlated with histopathology and comparison of conventional USG with other higher radio diagnostic modalities like CT, CECT and MRI in validating RMI: A prospective observational study in a tertiary care setting of Tamil Nadu [PDF]
, 2021 Sankaran Mirunalini +3 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Multi-Modal Loop Closing in Unstructured Planetary Environments with Visually Enriched Submaps [PDF]
, 2021 Riccardo Giubilato +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
An Improved Generalized Flexibility Sensitivity Method for Structural Damage Detection
Shanghai Jiaotong Daxue xuebaoThis paper proposes an improved generalized flexibility sensitivity method for structural damage detection. The proposed approach improves the accuracy of the original generalized flexibility sensitivity method by increasing the order of the sensitivity ...
NIU Zirong, WU Feng, HAN Zhaolong, ZHUO Yang, CHE Ailan, ZHU Hongbo
doaj +1 more source
Which signal modalities do cyclists prefer based on experiences in road traffic?
, 2021 Elke-Henriette Erdei +2 more
openalex +1 more source