Results 121 to 130 of about 1,454,061 (346)

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

An Improved Generalized Flexibility Sensitivity Method for Structural Damage Detection

Shanghai Jiaotong Daxue xuebao
This paper proposes an improved generalized flexibility sensitivity method for structural damage detection. The proposed approach improves the accuracy of the original generalized flexibility sensitivity method by increasing the order of the sensitivity ...
NIU Zirong, WU Feng, HAN Zhaolong, ZHUO Yang, CHE Ailan, ZHU Hongbo
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

İLK DÖNEM İSLÂM MANTIKÇILARININ MODAÜTEYE YAKLAŞIMI

Felsefe Dünyası, 2004
This study explores the modal propositions and modal syllogisms of Muslim logicians such as Farabi, Ibn Sina, Ghazali, Abu Salt al-Dani and Ibn Tumlus. Although they all discuss the modal propositions, only Ibn Sina and Abu Salt al-Dani consider modal ...
İbrahim Çapak
doaj  

UJI BEBAN DINAMIK DAN ANALISIS MODAL OPERASIONAL JEMBATAN BAJA KOMPOSIT UNDERPASS BEKAMBIT

Dinamika Rekayasa
Uji beban dinamik bertujuan untuk mengetahui tingkat keselamatan, keamanan dan kondisi awal kelaikan operasi jembatan. Penentuan kelaikan didasarkan dari penilaian parameter dinamik seperti frekuensi, rasio redaman, kekakuan dan pola getar diperoleh dari
Heri Khoeri, Sofia W. Alisjahbana, Panji Nugroho   +2 more
doaj   +1 more source

Opposite Hand Preferences in Two Sense-modalities [PDF]

, 1968
G. Ettlinger, Colin Blakemore, A. David Milner   +2 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Logical consequence in modal logic: Natural deduction in ${\rm S}5$. [PDF]

, 1969
John Corcoran, George Weaver
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cross-modal transfer of a specific discrimination in the rabbit [PDF]

, 1969
Arthur L. Yehle, Jeannette P. Ward
openalex   +1 more source