Results 121 to 130 of about 2,484,152 (338)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Traffic Volumes as a Modal Split Parameter [PDF]

, 2020
Marek Drličiak, Ján Čelko, Michal Cingel, Dušan Jandačka   +3 more
openalex   +1 more source

Modal Analysis of Conceptual Microsatellite Design Employing Perforated Structural Components for Mass Reduction [PDF]

, 2022
Sarmad Dawood Salman Dawood, Ahmad Salahuddin Mohd Harithuddin, Mohammad Yazdi Harmin   +2 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Parametric Modal Study and Optimization of the Floor Pan of a B-Segment Automotive Using a Hybrid Method of Taguchi and a Newly Developed MCDM Model

Latin American Journal of Solids and Structures
The floor pan is an important component that connects the front and rear segments of the automotive underbody structure. Global stiffness and NVH characteristics of BIW are highly dependent to shape, thickness and mass of the body panels and could be ...
Mohammad Hassan Shojaeefard, Abolfazl Khalkhali, Abdolah Tavakoli Lahijani   +2 more
doaj   +1 more source

Wilt Thou Be Lord of all the World? Modals and Persuasion in Shakespeare

Studia Anglica Posnaniensia, 2014
Persuasion is defined as human communication designed to influence the judgements and actions of others (Simons & Jones 2011). The purpose of this research is to analyse the discourse of persuasion in Shakespeare from the perspective of historical ...
Nakayasu Minako
doaj   +1 more source

Relasi Intelektual, Modal, dan Negara di Indonesia: Faktor-faktor Yang Mengkondisikan dan Implikasinya

Jurnal Politik, 2017
Dalam pengalaman relasi intelektual, modal dan negara pada era Reformasi, terdapat dua faktor yang mempengaruhi bagaimana relasi tersebut terbentuk. Secara struktural, faktor pertama ialah dorongan pencarian legitimasi politik oleh negara dan faktor ...
Muhammad Fajar
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Pengaruh Modal Kerja Terhadap Perkembangan Usaha Pada Koperasi Bina Mitra Sejahtera Universitas Nias

, 2022
Dedi Irawan Zebua
openalex   +2 more sources