Results 61 to 70 of about 1,234,147 (346)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Unicoder-VL: A Universal Encoder for Vision and Language by Cross-modal Pre-training [PDF]

AAAI Conference on Artificial Intelligence, 2019
We propose Unicoder-VL, a universal encoder that aims to learn joint representations of vision and language in a pre-training manner. Borrow ideas from cross-lingual pre-trained models, such as XLM (Lample and Conneau 2019) and Unicoder (Huang et al ...
Gen Li, Nan Duan, Yuejian Fang, Daxin Jiang, Ming Zhou   +4 more
semanticscholar   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Affective Computing: Recent Advances, Challenges, and Future Trends

Intelligent Computing
Affective computing is a rapidly growing multidisciplinary field that encompasses computer science, engineering, psychology, neuroscience, and other related disciplines.
Guanxiong Pei, Haiying Li, Yandi Lu, Yanlei Wang, Shizhen Hua, Taihao Li   +5 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Model-based iterative reconstruction with adaptive regularization for artifact reduction in electron tomography

Scientific Reports
Obtaining high-quality 3D reconstructions from electron tomography of crystalline particles embedded in lighter support elements is crucial for various material systems such as catalysts for fuel cell applications.
Singanallur Venkatakrishnan, Obaidullah Rahman, Lynda Amichi, Jose D. Arregui-Mena, Haoran Yu, David A. Cullen, Amirkoushyar Ziabari   +6 more
doaj   +1 more source

The Implementation of Debate Technique to Enhance the Students’ Speaking Skill

English Education Journal: Jurnal Pengembangan Pendidikan dan Pengembangan Pengajaran Bahasa, 2019
The objective of this research was to improve the quality of teaching and learning speaking by using debate technique at the tenth grade students of SMAN Modal Bangsa, Aceh. The academic year was 2017/2018.
Michael Tianame, Bustami Usman, Asnawi Muslem   +2 more
doaj  

GFFNet: Global Feature Fusion Network for Semantic Segmentation of Large-Scale Remote Sensing Images

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Semantic segmentation plays a pivotal role in interpreting high-resolution remote sensing images (RSIs), where contextual information is essential for achieving accurate segmentation.
Yong Cao, Chunlei Huo, Shiming Xiang, Chunhong Pan   +3 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source