Results 81 to 90 of about 1,520,948 (343)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Cross-modal Deep Metric Learning with Multi-task Regularization
, 2017 DNN-based cross-modal retrieval has become a research hotspot, by which users can search results across various modalities like image and text. However, existing methods mainly focus on the pairwise correlation and reconstruction error of labeled data ...
Huang, Xin, Peng, Yuxin
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
MODAL: A multilingual corpus annotated for modality [PDF]
, 2017 We have produced a corpus annotated for modality which amounts to approximately 20,000 words in English, French, and Italian. The annotation scheme is based on the notion of epistemic construction and virtually languageindependent. The annotation is rigorously evaluated by means of a newly developed strategy based on the alignment of the entire ...
Nissim, Malvina, Pietrandrea, Paola
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A comparison of modal flexibility method and modal curvature method in structural damage detection [PDF]
, 2010 Vibration based damage detection techniques examines the changes in dynamic properties of a structure such as frequency, mode shape and damping to indicate the presence of damage.
Zaharudin, Noor Sabrina
core
Does Treewidth Help in Modal Satisfiability?
, 2010 Many tractable algorithms for solving the Constraint Satisfaction Problem (CSP) have been developed using the notion of the treewidth of some graph derived from the input CSP instance.
A. Herzig +24 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Detection of Bessel beams with digital axicons
, 2014 We propose a simple method for the detection of Bessel beams with arbitrary radial and azimuthal indices, and then demonstrate it in an all-digital setup with a spatial light modulator.
Forbes, Andrew +6 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source