Results 121 to 130 of about 82,652 (246)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ambient and forced vibration tests of a box girder concrete bridge model
, 2011 4th International Operational Modal Analysis Conference, IOMAC 2011 -- 9 May 2011 through 11 May 2011 -- -- 110155In this paper, ambient and forced vibration tests of a box girder laboratory con-crete bridge model are described to obtain experimental ...
Bayraktar, A. +2 more
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2011 This paper presents a fuzzy reasoning based approach for modeling the distributed dynamics of a parallel flow heat exchanger. Distributed-parameter and lumped-parameter models of the heat exchanger are first derived.
Kidouche, M., Habbi, A.
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
An integrated permanent dynamic monitoring system of a tall building in central Italy
, 2019 This paper presents results of the dynamic monitoring of a 10-storey r.c. tower in central Italy, focusing on the effects of ambient conditions. The installed monitoring system consists of a set of three accelerometers located on the last floor of the ...
Marco Regni +3 more
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Analysis of Modal and Vibration Response of Gearbox of Urban Rail Train
Jixie chuandong, 2016 The gearbox is an important urban rail train transmission equipment. Aiming at the problem of the gearbox housing easily damaged caused by the vibration,by the Creo to create the three- dimensional modeling of box and transmission components,and then ...
Chen Zhongwei, 2Lu Ning, Yang Jianwei
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source