Results 121 to 130 of about 22,425,765 (287)

Analysis of Modal and Vibration Response of Gearbox of Urban Rail Train

Jixie chuandong, 2016
The gearbox is an important urban rail train transmission equipment. Aiming at the problem of the gearbox housing easily damaged caused by the vibration,by the Creo to create the three- dimensional modeling of box and transmission components,and then ...
Chen Zhongwei, 2Lu Ning, Yang Jianwei
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Modal analysis of a 100449 tdw bulk carrier for the amidships cargo hold structure.

Annals of "Dunărea de Jos" University of Galaţi: Fascicle XI Shipbuilding
A modal analysis of the ships’ structures is requested at any design step to check the possibility of local resonance occurring with onboard systems and equipment. The main study objective is to perform a local modal analysis of the amishships cargo hold
Elena Cristina Saltan, Leonard Domnișoru   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Operational modal analysis from flight test data

, 2013
In the framework of the operational modal analysis (OMA), several approaches have been developed for estimating the modal parameters, i.e., natural frequencies, damping ratios, and mode shapes.
COPPOTELLI, Giuliano, D. Tozzi, GRAPPASONNI, CHIARA   +2 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Modal Shape Analysis Using Thermal Imaging

Journal of Aerospace Technology and Management, 2015
In recent years, advances in aeronautical engineering field include, among others, the development of increasingly lightweight and flexible materials, allowing better performance of systems in applications such as Unmanned Aerial Vehicles, photographic ...
Jorge Henrique Bidinotto, Eduardo Morgado Belo   +1 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Development and application of automated OMA algorithms [PDF]

, 2019
Within the contest of vibration-based monitoring, the paper summarizes the conceptual development of automated procedures of modal parameter estimation (MPE) and modal tracking (MT).
Gentile C., Marrongelli G.
core