Results 101 to 110 of about 82,652 (246)

Experimental Modal Analysis of Scaled Car-body Sidewall for High-speed Vehicles

机车电传动, 2017
According to the theory of experimental modal analysis (EMA), SIMO analysis method, multi-reference point modal test, experimental modal test and modal parameters identification of the scaled 1:8 car-body’s sidewall were conducted.
LI Xujuan, MIAO Bingrong, SHI Yanmin, WANG Mingyue, YANG Zhongkun   +4 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Damage localization using experimental modal parameters and topology optimization [PDF]

, 2010
This work focuses on the developement of a damage detection and localization tool using the Topology Optimization feature of MSC.Nastran. This approach is based on the correlation of a local stiness loss and the change in modal parameters due to damages ...
Niemann, Hanno, Morlier, Joseph, Gourinat, Yves, Shahdin, Amir   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

FINITE ELEMENT MODEL UPDATING OF A HISTORICAL MINARET VIA OPERATIONAL MODAL ANALYSIS

, 2017
7th International Operational Modal Analysis Conference -- MAY 09-12, 2017 -- Ingolstadt, GERMANYFinite element method is commonly used for analysis of historical structures.
Hokelekli, E., Demir, A., Nohutcu, H., Ercan E., Ercan, E., Demir A., Hökelekli E., Nohutçu H.   +7 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Output-only modal testing and model validation of unreinforced masonry infill walls in reinforced concrete frames

, 2019
Unreinforced masonry (URM) infill walls in reinforced concrete (r.c.) buildings are prone to seismic damage due to combined in-plane (IP) and out-of-plane (OOP) loadings.
Rainieri Carlo, De Risi M. T., Di Domenico Mariano, Ricci P.   +3 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Modal mass in classical and operational modal analysis

, 2019
International Operational Modal Analysis Conference (8th. 2019. Copengahen, Denmark)The financing support given by Banco Santander through the Mobility Grants for Researchers of Professors of the University of Oviedo, is gratefully appreciated.
Brincker, R., Aenlle López, Manuel, Fernández Fernández, Pelayo   +2 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source