Results 81 to 90 of about 831,882 (288)

Asymptotic modal analysis and statistical energy analysis [PDF]

open access: yes
Asymptotic Modal Analysis (AMA) is a method which is used to model linear dynamical systems with many participating modes. The AMA method was originally developed to show the relationship between statistical energy analysis (SEA) and classical modal ...
Dowell, Earl H.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The Ontological Ground of the Alethic Modality [PDF]

open access: yes, 1994
This paper is concerned with the wholly metaphysical question of whether necessity and possibility rest on nonmodal foundations—whether the truth conditions for modal statements are, in the final analysis, nonmodal.
Shalkowski, S.A.
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Analysis of flexible aircraft longitudinal dynamics and handling qualities. Volume 2: Data [PDF]

open access: yes
Two analysis methods are applied to a family of flexible aircraft in order to investigate how and when structural (especially dynamic aeroelastic) effects affect the dynamic characteristics of aircraft.
Schmidt, D. K., Waszak, M. R.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Vibration Modal Analysis of a New Type of Automobile Transmission Housing

open access: yesJixie chuandong, 2016
Based on the transmission housing which is designed independently by Automotive Engineering Technology Research Institute of Hefei University of Technology,the three- dimensional modeling of the housing is built by using Pro / E software,then imported in
Tao Xiaomin, Wang Shaojie
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Analysis on Modal Distribution and Modal Density-Based Crossover Frequency in Cabin-Sized Enclosures

open access: yesArchives of Acoustics
In the sound field simulation of cabin-sized enclosures, the Schroeder frequency (SF) is still employed to estimate the crossover frequency (CF) that determines the validity ranges of wave-based and geometrical acoustic methods.
Ziyu Wang, Liangfen Du, Guangzheng Yu
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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