Results 61 to 70 of about 109,890 (246)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Vibration Modal Analysis of a New Type of Automobile Transmission Housing
Jixie chuandong, 2016 Based on the transmission housing which is designed independently by Automotive Engineering Technology Research Institute of Hefei University of Technology,the three- dimensional modeling of the housing is built by using Pro / E software,then imported in
Tao Xiaomin, Wang Shaojie
doaj
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Jixie chuandong, 2013 Based on the method of PolyMAX,a system of modal analysis is built,the model of JZQ-250 gear-box is set up under the LMS modal analysis module.The relating modal datum are obtained by hammering test of single-input multi-output analysis method,then the ...
王佳, 潘宏侠, 杨晓波
doaj
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Analysis on Modal Distribution and Modal Density-Based Crossover Frequency in Cabin-Sized Enclosures
Archives of AcousticsVehicle cabins, as typical small-scale enclosures, exhibit modal characteristics critical to sound field control. Existing modal property formulations—most notably the Schroeder frequency, which distinguishes sparse and dense modal distributions via ...
Ziyu Wang, Liangfen Du, Guangzheng Yu
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Review of Structural Modal Tracking in Operational Modal Analysis: Methods and Applications
Applied SciencesModal tracking has evolved into a crucial research domain over the past decades. It synergizes with automatic modal parameter estimation (AMPE) to achieve automatic operational modal analysis (AOMA).
Shenghui Fu, Jie Wu
doaj +1 more source