Results 71 to 80 of about 127,288 (293)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

基于PolyMAX法的齿轮箱试验模态分析

Jixie chuandong, 2013
Based on the method of PolyMAX,a system of modal analysis is built,the model of JZQ-250 gear-box is set up under the LMS modal analysis module.The relating modal datum are obtained by hammering test of single-input multi-output analysis method,then the ...
王佳, 潘宏侠, 杨晓波
doaj  

MODAL ANALYSIS OF SEISMIC FORCES FOR LIGHT-WEIGHT BENDING BEAM FIXED AT ONE END AND PIN-SUPPORTED AT THE OTHER IN A MULTISTORY BUILDING

, 2022
Tadashi Ishihara, Yusuke Oki, Shoichi KISHIKI   +2 more
openalex   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Analysis on Modal Distribution and Modal Density-Based Crossover Frequency in Cabin-Sized Enclosures

Archives of Acoustics
Vehicle cabins, as typical small-scale enclosures, exhibit modal characteristics critical to sound field control. Existing modal property formulations—most notably the Schroeder frequency, which distinguishes sparse and dense modal distributions via ...
Ziyu Wang, Liangfen Du, Guangzheng Yu
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Application of Experimental Modal Analysis to Determine Damping Properties for Stacked Corrugated Boxes [PDF]

, 2013
Changfeng Ge, Steven C. Sutherland
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Review of Structural Modal Tracking in Operational Modal Analysis: Methods and Applications

Applied Sciences
Modal tracking has evolved into a crucial research domain over the past decades. It synergizes with automatic modal parameter estimation (AMPE) to achieve automatic operational modal analysis (AOMA).
Shenghui Fu, Jie Wu
doaj   +1 more source

INFLUENCE OF HOUSING RIBBING MODIFICATION ON FREQUENCIES AND SHAPES OF VIBRATIONS [PDF]

Scientific Journal of Silesian University of Technology. Series Transport, 2014
In article an experimental and theoretical modal analysis of selected structural solutions of housings gear was carried out. Results of the examinations enabled to determine a rate of FEM modal parameters conformity with parameters of actual objects by ...
Piotr FOLĘGA, Grzegorz WOJNAR, Piotr CZECH   +2 more
doaj