Results 131 to 140 of about 2,942,391 (249)
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Modal Identification of Output-Only Systems of Composite Discs Using Zernike Modes and MAC. [PDF]
Sensors (Basel), 2019 Nguyen M +3 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Operational modal analysis of low frequency surface waves in Lakes and reservoirs
, 2019 Wind driven oscillations of water surfaces (surface seiches) are a key driver of ecological fluxes, such as of oxygen and nutrients, within lakes and reservoirs.
Bouffard, Damien (author) +4 more
core +1 more source
Modal Identification in an Automotive Multi-Component System Using HS 3D-DIC. [PDF]
Materials (Basel), 2018 Molina-Viedma ÁJ +3 more
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Dynamic identification of moumental and historical minaret of the Sehadet
, 2015 Modal analysis has been used in three decades in the civil engineering disciplines in order to solve complex structural dynamic problems. In this study, dynamic parameter such as fundamental frequency, mode shapes and damping ratios of minaret of Sehadet
Livaoǧlu, Ramazan +2 more
core
Modal Identification and Finite Element Updating of a Stress-Ribbon Bridge
, 2004 The paper describes the ambient vibration testing, modal identification and finite element updating of an existingstress-ribbon bridge, so as to create a reliable numerical model that enables the accurate numerical simulation ofthe dynamic behaviour of ...
Elsa Caetano, Álvaro Cunha
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source