Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
On the robustness of the average power ratios in damping estimation: application in the structural health monitoring of composites beams [PDF]
In composites structures, cracking, delamination will cause changes in the measured dynamic response of structure and so on experimentally modal parameters.
J. Morlier +4 more
core +1 more source
A New Maximum Likelihood Estimator Formulated in Pole-Residue Modal Model
Recently, a lot of efforts have been devoted to developing more precise Modal Parameter Estimation (MPE) techniques. This is explained by the necessity in civil, mechanical and aerospace engineering of obtaining accurate estimates for the modal ...
Sandro Amador +3 more
doaj +1 more source
Identification of modal parameters using the wavelet transform
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Lardies, Joseph, Gouttebroze, Stéphane
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
To accurately determine the temperature-dependent parameters of composites, a thermo-elastic parameter identification approach using thermal modal data is proposed in this article.
Dong Jiang +3 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Significance of low energy impact damage on modal parameters of composite beams by design of experiments [PDF]
This paper presents an experimental study on the effects of multi-site damage on the vibration response of composite beams damaged by low energy impacts around the barely visible impact damage limit (BVID).
A Shahdin +6 more
core +1 more source
On-Line Modal Parameter Identification Applied to Linear and Nonlinear Vibration Absorbers
A solution of the vibration attention problem on a flexible structure from a dynamic vibration absorption perspective is experimentally and numerically studied in this article.
Luis Gerardo Trujillo-Franco +4 more
doaj +1 more source

