Results 101 to 110 of about 25,430 (307)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Real-Time Adaptive Control Of Modal Synthesis

, 2003
Description
Reynald Hoskinson, Kees van den Doel, Sidney S. Fels   +2 more
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Use of Modal Synthesis for Composite Structures

Scientific Proceedings Faculty of Mechanical Engineering, 2014
Abstract A common occurrence in engineering practice is undesirable levels of vibration in the structures of machinery, which decrease their functionality, safety, reliability and service life. Current trends in the dynamic operation of machinery inherently generate such undesirable effects.
Miloš Musil, Ondrej Chlebo
openaire   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

AnomalyXFusion: Multi-modal Anomaly Synthesis with Diffusion

CoRR
Anomaly synthesis is one of the effective methods to augment abnormal samples for training. However, current anomaly synthesis methods predominantly rely on texture information as input, which limits the fidelity of synthesized abnormal samples. Because texture information is insufficient to correctly depict the pattern of anomalies, especially for ...
Jie Hu, Yawen Huang, Yilin Lu, Guoyang Xie, Guannan Jiang, Yefeng Zheng 0001, Zhichao Lu   +6 more
openaire   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Simulation of Transient Nonlinear Friction-Induced Vibrations Using Complex Interface Modes: Application to the Prediction of Squeal Events

Shock and Vibration, 2017
During the past decades, the problem of friction-induced vibration and noise has been the subject of a huge amount of works. Various numerical simulations with finite elements models have been largely investigated to predict squeal events.
J.-J. Sinou, S. Besset
doaj   +1 more source

A modality separation approach for facial sketch synthesis

IET Image Processing
Abstract The technology for face‐to‐sketch synthesis transforms optical face images into a sketch‐style format. However, traditional style losses are insufficient to discern the modal differences between optical and sketch domain images, leading to unclear images.
Kangning Du, Chaoyi Wang, Lin Cao, Yanan Guo, Wenwen Sun   +4 more
openaire   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source