Results 71 to 80 of about 22,495 (265)

Synergistic interplay of deep eutectic solvents and multi-modal extraction techniques: A paradigm shift in natural polysaccharide yield, structural modulation, and biofunctional enhancement

Industrial Crops and Products
Natural polysaccharides are essential macromolecules found in both plant and animal kingdoms, playing significant roles in food, medicine, biomaterials, and packaging.
Yan Sun, Fei Wang, Zihan Li, Xifeng Chen, Quanliang Xie, Zhuang Meng, Haitao Shen, Shandang Shi, Hongbin Li   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mistuning Identification and Model Updating of an Industrial Blisk

International Journal of Rotating Machinery, 2007
The results of a complete study of mistuning identification on an industrial blisk are presented. The identification method used here is based on a model-updating technique of a reduced order.
D. Laxalde, F. Thouverez, J.-J. Sinou, J.-P. Lombard, S. Baumhauer   +4 more
doaj   +1 more source

Composing Comes Alive: Dramatic Presentations in the Writing Classroom

Prompt, 2019
In creating and presenting a collaborative dramatic presentation of a literary text, composition students bring "The Yellow Wallpaper" to life through close reading, literary analysis and synthesis, recursive multi-modal writing, and group performance ...
Ann E. Wallace
doaj   +1 more source

Maximally Permissive Controlled System Synthesis for Modal Logic [PDF]

, 2015
SOFSEM ...
van Hulst, Allan C., Reniers, Michel A., Fokkink, Wan   +2 more
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Spatial-Temporal and Multi-Modal Collaborative Optimization Framework for RGBT Counter-Drone Tracking

IEEE Access
This paper tackles the challenges of tracking high-speed maneuvering low-altitude drones amid cross-modal heterogeneity and complex background interference by proposing STMMC, a spatial-temporal and multi-modal collaborative optimization framework for ...
Xin Ning, Hongchang Ding, Han Hou, Xiaoqiang Guo   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source