Results 91 to 100 of about 848,455 (289)

English future tense revisited [PDF]

Zbornik Radova Filozofskog Fakulteta u Prištini, 2018
Tense is the typical grammatical marker of the semantic category of temporality. However, there is rarely a clear-cut distinction among temporal, aspectual and modal meanings.
Radovanović Aleksandra M.
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Modality-independent coding of spatial layout in the human brain.

, 2018
In many nonhuman species, neural computations of navigational information such as position and orientation are not tied to a specific sensory modality [1, 2].
Nicholas A. Giudice (5421920), Roberta Klatzky (3888550), Jack M. Loomis (369303), Thomas Wolbers (5425148), Magdalena G. Wutte (5425151)   +4 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Proof of concept 3D ultrasound strain imaging measuring effect of a ring pessary on avulsed puborectal muscle

Communications Medicine
Background Placement or fitting of a ring pessary is one of the treatment options for women with pelvic organ prolapse (POP), resulting from avulsion. To determine the effect of ring pessary use in these women, usually qualitative measures like a patient
Shreya Das, Gijs A. G. M. Hendriks, Frieda van den Noort, Claudia Manzini, Carl H. van der Vaart, Chris L. de Korte   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

In-vivo optical properties spectra across five body locations on ten subjects using time-domain diffuse optics

Scientific Data
We present a comprehensive dataset of absorption and reduced scattering spectra collected via time-domain diffuse optical spectroscopy in the 610-1110 nm range, across 10 subjects and on 5 different body locations – the upper arm, the radius-ulna region,
Vamshi Damagatla, Siënna Karremans, Alessandro Bossi, Edoardo Martinenghi, Srirang Manohar, Paola Taroni, Rinaldo Cubeddu, Antonio Pifferi, Ilaria Bargigia   +8 more
doaj   +1 more source

STRUCTURAL-SEMANTIC TYPES OF THE COMBINATION OF THE VERB LASSEN WITH AN INFINITIVE

Вестник Кемеровского государственного университета, 2017
The  article  examines  the  combination  of  the  German  verb  lassen with an infinitive as an entire infinitival structure, where each component influences the creation of grammatical meanings of the whole structure. On the basis of this point of view
O. A. Smetanina
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source