Results 81 to 90 of about 848,455 (289)

Digital task management platform enhances student academic achievement in economic development education

Discover Education
Based on self-regulated learning theory, a study at Universidad del Norte examined Trello's impact on student performance in an undergraduate Economic Development course. The quasi-experimental research involved 103 students across two semesters, with 52
Heidy Rico Fontalvo, Florentino Rico, Mario de la Puente, Tatiana Londoño, Daniela Navarro   +4 more
doaj   +1 more source

Impact of Injection Technique on Microsphere Distribution During Transarterial Radioembolization in a Successively Bifurcating In Vitro Model

Advances in Radiation Oncology
Purpose: This study aimed to experimentally investigate how injection technique affects the distribution of microspheres during transarterial radioembolization in a successively bifurcating in vitro model.
Tess J. Snoeijink, MSc, Jan L. van der Hoek, MSc, Anne van den Brekel, MSc, Gerhard van Wolfswinkel, MSc, Marcel J.R. Janssen, MD, PhD, Erik Groot Jebbink, PhD, J. Frank W. Nijsen, PhD   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

3D ultrasound guidance for radiofrequency ablation in an anthropomorphic thyroid nodule phantom

European Radiology Experimental
Background The use of two-dimensional (2D) ultrasound for guiding radiofrequency ablation (RFA) of benign thyroid nodules presents limitations, including the inability to monitor the entire treatment volume and operator dependency in electrode ...
Tim Boers, Sicco J. Braak, Wyger M. Brink, Michel Versluis, Srirang Manohar   +4 more
doaj   +1 more source

Investigating the Semantic Development of Modal Markers: The Role of Context

Clotho, 2019
The article tackles the problem of studying diachronic semantic changes of modal markers in Latin. It proposes to do so by using context as a proxy for tracing the development of otherwise unchanging forms.
Tomaž Potočnik, Matej Hriberšek
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Derivational Modal Logics with the Difference Modality [PDF]

, 2014
In this chapter we study modal logics of topological spaces in the combined language with the derivational modality and the difference modality. We give axiomatizations and prove completeness for the following classes: all spaces, $T_1$-spaces, dense-in-themselves spaces, a zero-dimensional dense-in-itself separable metric space, $R^n$ $(n\ge 2)$.
Kudinov, Andrey, Shehtman, Valentin
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source