Results 81 to 90 of about 567,731 (269)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Scientific DataWe present a comprehensive dataset of absorption and reduced scattering spectra collected via time-domain diffuse optical spectroscopy in the 610-1110 nm range, across 10 subjects and on 5 different body locations – the upper arm, the radius-ulna region,
Vamshi Damagatla +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
STRUCTURAL-SEMANTIC TYPES OF THE COMBINATION OF THE VERB LASSEN WITH AN INFINITIVE
Вестник Кемеровского государственного университета, 2017 The article examines the combination of the German verb lassen with an infinitive as an entire infinitival structure, where each component influences the creation of grammatical meanings of the whole structure. On the basis of this point of view
O. A. Smetanina
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Author Correction: Optical signatures of radiofrequency ablation in biological tissues
Scientific Reports, 2021 Pranav Lanka +7 more
doaj +1 more source
Modals and Modality in English
Miscelánea: A Journal of English and American Studies, 1995 Modality as a linguistic notion has a clear expression in English through the use of different modal verbs. In this respect, we can approach this fact from both a diachronic and a synchronic perspective. In the development of modals in time, it is interesting to consider Bernd Heine's account, for whom modals' development should be considered within a ...
openaire +2 more sources
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source