Results 61 to 70 of about 741,275 (315)

Mixed-methods evaluation of the implementation of IOTA-ADNEX ultrasound triage in NHS secondary care ovarian diagnostic one-stop clinics

BMJ Open Quality
Objectives Robust evidence supports International Ovarian Tumour Analysis (IOTA)-Assessment of Different Neoplasias in the Adnexa (ADNEX) ultrasound triage at 10% threshold for ovarian cancer (OC) diagnosis to identify women for referral to tertiary ...
Sudha Sundar, Carole Cummins, Grisham Smotra, Sarada Kannangara, Helen Crisp, Aamena Salar, Omiete Duke, Nina Jhita, Vivian Do, Becky Tarbuck, Vincent Sai, Naresh Rati   +11 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Selective agonists of KIR and NKG2A to evade missing self response of natural killer cells

Scientific Reports
Immune rejection is one of the most serious challenges in allogeneic transplantation, including allogeneic induced pluripotent stem cell (allo-iPSC)-derived cell therapy. Beta-2-Microglobulin gene-knockout, human leukocyte antigen (HLA) class I-deficient
Satoshi Hiura, Yuto Kuwasaki, Yosuke Nishikawa, Takako Kimura, Sayaka Yoshida, Makiko Nakayama, Tomohiro Makino, Suguru Ueno   +7 more
doaj   +1 more source

Deep learning-based segmentation of 3D ultrasound images of the thyroid

WFUMB Ultrasound Open
The goal of the study was to develop a method for segmentation of the thyroid, carotid artery (CA), and jugular vein (JV) using 3D ultrasound data. This method forms the basis for a computer-assisted needle-based intervention for thyroid nodules and ...
Roxane Munsterman, Tim Boers, Sicco J. Braak, Jelmer M. Wolterink, Michel Versluis, Srirang Manohar   +5 more
doaj   +1 more source

Sequence-of-tense and the features of finite tenses

Nordlyd: Tromsø University Working Papers on Language & Linguistics, 2015
Sequence-of-tense (SOT) is often described as a (past) tense verb form that does not correspond to a semantically interpretable tense. Since SOT clauses behave in other respects like finite clauses, the question arises as to whether the syntactic ...
Karen Zagona
doaj   +1 more source

Presentation modality influences behavioral measures of alerting, orienting, and executive control [PDF]

, 2006
The Attention Network Test (ANT) uses visual stimuli to separately assess the attentional skills of alerting (improved performance following a warning cue), spatial orienting (an additional benefit when the warning cue also cues target location), and ...
Hall, Deborah A.; id_orcid, Roberts, KL, Roberts, Katherine L., Hall, Deborah A., Hall, DA, Deborah A. Hall, A. Quentin Summerfield, Summerfield, AQ, Summerfield, A. Quentin, Katherine L. Roberts   +9 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effectiveness of a structured emotional literacy and stress management program for female heads of household: a two-year longitudinal study in Cartagena, Colombia, and Valencia, Venezuela

Critical Public Health
Female heads of household face unique stressors related to economic survival and family care, yet few evidence-based interventions address their specific emotional health needs.
Heidy Rico, Mario de la Puente, Florentino Rico, Tatiana Londoño   +3 more
doaj   +1 more source

The Meaning of Modality [PDF]

Cognitive Science, 1978
This paper describes a semantics for modal terms such as can and may that is intended to model the mental representation of their meaning. The basic assumption of the theory is that the evaluation of a modal assertion involves an attempted mental construction of a specified alternative to a given situation rather than the separate evaluation of each ...
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source