Results 61 to 70 of about 340,881 (244)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Telehealth and people with disabilities in the United Kingdom: a scoping review

Frontiers in Public Health
IntroductionTelehealth, also sometimes known as telemedicine, is the use of communication technologies to deliver healthcare remotely, has become increasingly vital, particularly since the COVID-19 pandemic. While telehealth can improve healthcare access,
Mezhen Ko, Mezhen Ko, Matthew Azzopardi, Constantinos Loizou, Abison Logeswaran, Benjamin Ng, Agata Pacho, Yu Jeat Chong   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Selective agonists of KIR and NKG2A to evade missing self response of natural killer cells

Scientific Reports
Immune rejection is one of the most serious challenges in allogeneic transplantation, including allogeneic induced pluripotent stem cell (allo-iPSC)-derived cell therapy. Beta-2-Microglobulin gene-knockout, human leukocyte antigen (HLA) class I-deficient
Satoshi Hiura, Yuto Kuwasaki, Yosuke Nishikawa, Takako Kimura, Sayaka Yoshida, Makiko Nakayama, Tomohiro Makino, Suguru Ueno   +7 more
doaj   +1 more source

Deep learning-based segmentation of 3D ultrasound images of the thyroid

WFUMB Ultrasound Open
The goal of the study was to develop a method for segmentation of the thyroid, carotid artery (CA), and jugular vein (JV) using 3D ultrasound data. This method forms the basis for a computer-assisted needle-based intervention for thyroid nodules and ...
Roxane Munsterman, Tim Boers, Sicco J. Braak, Jelmer M. Wolterink, Michel Versluis, Srirang Manohar   +5 more
doaj   +1 more source

Sequence-of-tense and the features of finite tenses

Nordlyd: Tromsø University Working Papers on Language & Linguistics, 2015
Sequence-of-tense (SOT) is often described as a (past) tense verb form that does not correspond to a semantically interpretable tense. Since SOT clauses behave in other respects like finite clauses, the question arises as to whether the syntactic ...
Karen Zagona
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Association between breastfeeding and pelvic floor dysfunction: a systematic review

BMC Pregnancy and Childbirth
Background This systematic review evaluates the association between breastfeeding and pelvic floor (dys)function. Since breastfeeding has well-known positive effects, exclusive breastfeeding is recommended for the first 6 months after birth.
Claudia Manzini, Mart Christiaan Paul Kortman, Nienke Bosschaart, Anique Theodora Maria Grob   +3 more
doaj   +1 more source

Effectiveness of a structured emotional literacy and stress management program for female heads of household: a two-year longitudinal study in Cartagena, Colombia, and Valencia, Venezuela

Critical Public Health
Female heads of household face unique stressors related to economic survival and family care, yet few evidence-based interventions address their specific emotional health needs.
Heidy Rico, Mario de la Puente, Florentino Rico, Tatiana Londoño   +3 more
doaj   +1 more source

Multimodal integration of spatial information: The influence of object-related factors and self-reported strategies

Frontiers in Psychology, 2016
Spatial representations are a result of multisensory information integration. More recent findings suggest that the multisensory information processing of a scene can be facilitated when paired with a semantically congruent auditory signal.
Harun Karimpur, Kai Hamburger
doaj   +1 more source