Results 41 to 50 of about 534,974 (269)

Modal Predicates

The Australasian Journal of Logic, 2004
Despite the wide acceptance of standard modal logic, there has always been a temptation to think that ordinary modal discourse may be correctly analyzed and adequately represented in terms of predicates rather than in terms of operators. The aim of the formal model outlined in this paper is to capture what I take to be the only plausible sense in which
openaire   +4 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Telehealth and people with disabilities in the United Kingdom: a scoping review

Frontiers in Public Health
IntroductionTelehealth, also sometimes known as telemedicine, is the use of communication technologies to deliver healthcare remotely, has become increasingly vital, particularly since the COVID-19 pandemic. While telehealth can improve healthcare access,
Mezhen Ko, Mezhen Ko, Matthew Azzopardi, Constantinos Loizou, Abison Logeswaran, Benjamin Ng, Agata Pacho, Yu Jeat Chong   +7 more
doaj   +1 more source

On Actuality Entailments, Causation, and Telicity in Balkar

Languages, 2023
This paper presents a study of actuality entailments in Balkar (a dialect of Karachay-Balkar, Turkic). The study focuses on the deontic and causal meanings of four morphemes: two suffixes (the causative suffix and the suffix -al (‘can/may’)) and two ...
Dmitry Privoznov
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Selective agonists of KIR and NKG2A to evade missing self response of natural killer cells

Scientific Reports
Immune rejection is one of the most serious challenges in allogeneic transplantation, including allogeneic induced pluripotent stem cell (allo-iPSC)-derived cell therapy. Beta-2-Microglobulin gene-knockout, human leukocyte antigen (HLA) class I-deficient
Satoshi Hiura, Yuto Kuwasaki, Yosuke Nishikawa, Takako Kimura, Sayaka Yoshida, Makiko Nakayama, Tomohiro Makino, Suguru Ueno   +7 more
doaj   +1 more source

Deep learning-based segmentation of 3D ultrasound images of the thyroid

WFUMB Ultrasound Open
The goal of the study was to develop a method for segmentation of the thyroid, carotid artery (CA), and jugular vein (JV) using 3D ultrasound data. This method forms the basis for a computer-assisted needle-based intervention for thyroid nodules and ...
Roxane Munsterman, Tim Boers, Sicco J. Braak, Jelmer M. Wolterink, Michel Versluis, Srirang Manohar   +5 more
doaj   +1 more source

Sequence-of-tense and the features of finite tenses

Nordlyd: Tromsø University Working Papers on Language & Linguistics, 2015
Sequence-of-tense (SOT) is often described as a (past) tense verb form that does not correspond to a semantically interpretable tense. Since SOT clauses behave in other respects like finite clauses, the question arises as to whether the syntactic ...
Karen Zagona
doaj   +1 more source

Modal Expansionism [PDF]

Journal of Philosophical Logic, 2019
There are various well-known paradoxes of modal recombination. This paper offers a solution to a variety of such paradoxes in the form of a new conception of metaphysical modality. On the proposed conception, metaphysical modality exhibits a type of indefinite extensibility.
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source