Results 61 to 70 of about 534,974 (269)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Exploring modality switching effects in negated sentences: Further evidence for grounded representations

Frontiers in Psychology, 2013
Theories of embodied cognition (e.g., Perceptual Symbol Systems Theory; Barsalou, 1999, 2009) suggest that modality-specific simulations underlie the representation of concepts.
Lea eHald, Lea eHald, Ian eHocking, David eVernon, Julie-Ann eMarshall, Julie-Ann eMarshall, Alan eGarnham   +6 more
doaj   +1 more source

MODAL: A multilingual corpus annotated for modality [PDF]

, 2017
We have produced a corpus annotated for modality which amounts to approximately 20,000 words in English, French, and Italian. The annotation scheme is based on the notion of epistemic construction and virtually languageindependent. The annotation is rigorously evaluated by means of a newly developed strategy based on the alignment of the entire ...
Nissim, Malvina, Pietrandrea, Paola
openaire   +3 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Digital task management platform enhances student academic achievement in economic development education

Discover Education
Based on self-regulated learning theory, a study at Universidad del Norte examined Trello's impact on student performance in an undergraduate Economic Development course. The quasi-experimental research involved 103 students across two semesters, with 52
Heidy Rico Fontalvo, Florentino Rico, Mario de la Puente, Tatiana Londoño, Daniela Navarro   +4 more
doaj   +1 more source

Impact of Injection Technique on Microsphere Distribution During Transarterial Radioembolization in a Successively Bifurcating In Vitro Model

Advances in Radiation Oncology
Purpose: This study aimed to experimentally investigate how injection technique affects the distribution of microspheres during transarterial radioembolization in a successively bifurcating in vitro model.
Tess J. Snoeijink, MSc, Jan L. van der Hoek, MSc, Anne van den Brekel, MSc, Gerhard van Wolfswinkel, MSc, Marcel J.R. Janssen, MD, PhD, Erik Groot Jebbink, PhD, J. Frank W. Nijsen, PhD   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

3D ultrasound guidance for radiofrequency ablation in an anthropomorphic thyroid nodule phantom

European Radiology Experimental
Background The use of two-dimensional (2D) ultrasound for guiding radiofrequency ablation (RFA) of benign thyroid nodules presents limitations, including the inability to monitor the entire treatment volume and operator dependency in electrode ...
Tim Boers, Sicco J. Braak, Wyger M. Brink, Michel Versluis, Srirang Manohar   +4 more
doaj   +1 more source