Results 101 to 110 of about 8,098,138 (300)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Sustaining Science Infrastructure Is Difficult; Is Commercialization the Answer? The USA National Phenology Network's Experience

Perspectives of Earth and Space Scientists
Biological and physical science infrastructure programs play a critical role in supporting scientific discovery. Even with their foundational roles in the process of science, frequently, support for these programs is threatened, reduced, or eliminated ...
T. M. Crimmins, J. Clark
doaj   +1 more source

Perception of Western Musical Modes: A Chinese Study

Frontiers in Psychology, 2017
The major mode conveys positive emotion, whereas the minor mode conveys negative emotion. However, previous studies have primarily focused on the emotions induced by Western music in Western participants. The influence of the musical mode (major or minor)
Lele Fang, Lele Fang, Junchen Shang, Junchen Shang, Nan Chen, Nan Chen   +5 more
doaj   +1 more source

Edge modes without edge modes

, 2021
We discuss gauge theories of the Yang-Mills kind in finite regions with boundaries, and in particular the definition of the corresponding quasi-local degrees of freedom and their gluing upon composition of the underlying regions. Although the most of the technical results presented here has appeared in previous works by Gomes, Hopfm ller and the ...
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Retention and intentions of professional accountants [PDF]

, 2012
This paper enhances understanding of factors underlying professional accountants’ high turnover rates. Various researchers, institutions and government bodies have identified accountants’ retention is of concern.
Samujh, Helen, Twiname, Linda J., Van Lamoen, Nils Karel   +2 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Effects of Mode Shares on Mode Choice [PDF]

This study considers the influence of the knowledge of existing mode shares on travelers mode choice. This contrasts with traditional mode choice models, where the main objective is to predict the overall mode shares as the aggregate of individual mode ...
Carlos Carrion, David Levinson, Nebiyou Tilahun   +2 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source