Results 111 to 120 of about 8,132 (255)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Towards unified AI-driven fracture mechanics: the extended deep energy method (XDEM). [PDF]

Nat Commun
Wang Y, Lin Y, Goswami S, Zhao L, Zhang H, Bai J, Anitescu C, Sadegh Eshaghi M, Zhuang X, Rabczuk T, Liu Y.   +10 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Unusual Failures Associated with Cracks That Nucleated from Corrosion Damage in Fatigue Tests on AA 7085-T7452 Specimens. [PDF]

Materials (Basel)
Peng D, Ang ASM, Phan N, Brindza MR, Main B, Jones R.   +5 more
europepmc   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Study on the Characteristic Size Effect of Crack Propagation in Rocks with Pre-existing Crack under the Same Strain Rate

工程科学与技术
ObjectiveDynamic loading-induced crack propagation in defect-containing rocks exhibits pronounced size dependency, which is critical for geotechnical practices such as blasting excavation and rockburst prevention.
WEN Lei, LU Wenkai, MA Fuchao, WANG Yangzhe, CAO Wenzhi, CAO Peiwang   +5 more
doaj  

Failure analysis of coal-rock composites with different coal thicknesses under uniaxial loading based on resistivity response and damage evolution. [PDF]

Sci Rep
Tian C, Liu J, Liu J, Liu W, Wang W, Liu B, Sun Y.   +6 more
europepmc   +1 more source

Modelling small fatigue crack propagation under mixed mode II+III loading

Procedia Structural Integrity, 2022
Nataliya Yadzhak, Oleksandr Andreykiv, Yuri Lapusta   +2 more
openaire   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

A closed-loop framework integrating robotic inspection and digital twins for fatigue prognosis of in-service steel bridges. [PDF]

Commun Eng
Li X, Fu Z, Guo H, Ji B, Xu Z.
europepmc   +1 more source