Results 111 to 120 of about 133,565 (298)

Nonlinear lattice model of viscoelastic Mode III fracture

, 2000
We study the effect of general nonlinear force laws in viscoelastic lattice models of fracture, focusing on the existence and stability of steady-state Mode III cracks.
A. Paskin, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. Holland, David A. Kessler, E. Brener, E. Sharon, E. Sharon, Herbert Levine, J. A. Hauch, J. Fineberg, J. Fineberg, J. Fineberg, J. S. Langer, L. I. Slepyan, M. Marder, M. Marder, O. Pla, P. Gumbsch, S. J. Zhou, Sh. A. Kulamekhtova   +22 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Droplet infiltration dynamics and soil wettability related to soil organic matter of soil aggregate coatings and interiors

Journal of Hydrology and Hydromechanics, 2016
The organo-mineral coatings of soil aggregates, cracks, and biopores control sorption and macropore-matrix exchange during preferential flow, in particular in the clay-illuvial Bt-horizon of Luvisols.
Fér Miroslav, Leue Martin, Kodešová Radka, Gerke Horst H., Ellerbrock Ruth H.   +4 more
doaj   +1 more source

Investigation of the effects of NaOH dopant level on the physical and mechanical properties of carbon/phenolic composite material [PDF]

, 1985
The near-catastrophic erosion of the STS-8A solid rocket booster nozzle was the instigating factor in the recent, and on-going, intensive investigation of carbon/phenolic composite materials.
Clinton, R. G., Jr.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Experimental and Numerical Study of the Tensile Behavior of Dam Concrete

Buildings
Tensile behavior governs the seismic safety of high concrete dams. This study integrates testing with mesoscale simulation to elucidate the tensile-failure mechanisms of dam fully graded concrete.
Kunhang Zhang, Shengshan Guo, Deyu Li, Haibo Wang   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Dynamics of Simple Cracks

, 2009
Cracks are the major vehicle for material failure, and often exhibit rather complex dynamics. The laws that govern their motion have remained an object of constant study for nearly a century.
Bouchbinder, Eran, Fineberg, Jay, Marder, M.   +2 more
core   +1 more source