Results 91 to 100 of about 133,565 (298)

Failure assessment of lightly reinforced floor slabs. I: Experimental investigation [PDF]

, 2011
This paper is concerned with the ultimate behavior of lightly reinforced concrete floor slabs under extreme loading conditions. Particular emphasis is given to examining the failure conditions of idealized composite slabs which become lightly reinforced ...
Cashell, KA, Elghazouli, AY, Izzuddin, BA   +2 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Origin of Crack Tip Instabilities

, 1994
This paper demonstrates that rapid fracture of ideal brittle lattices naturally involves phenomena long seen in experiment, but which have been hard to understand from a continuum point of view.
Ashurst, Atkinson, Bergkvist, Bergkvist, Celli, Cotterell, Doyle, Döll, Fineberg, Fineberg, Freund, Freund, Fuller, Gao, Gilman, Gradshteyn, Green, Gross, Jackson, Kanninen, Katsamanis, Knauss, Kobayashi, Kulamekhtova, Langer, Langer, Liu, Liu, M. Marder, Machová, Manneville, Marder, Marder, Mecholsky, Noble, Perrin, Ravi-Chandar, Rice, Sieradzki, Slepyan, Slepyan, Slepyan, Steve Gross, Takahashi, Thomson, Thomson, Washabaugh, Willis, Xu, Yoffe, Zhou   +50 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental study on the influence of non-penetrating crack spatial distribution on brittle fracture process

Scientific Reports
To gain insights into the spatial distribution of non-penetrating cracks during the rock fracture process, a comprehensive uniaxial compression test is conducted on cubic gypsum specimens (100 mm × 100 mm × 100 mm) containing two non-penetrating cracks ...
Jun Xu, Sen Luo, Xiaochun Xiao, Jiaxu Jin   +3 more
doaj   +1 more source

Fatigue Crack Growth under Mode I, II and III for Plane-strain and Plane-stress Conditions

Procedia Engineering, 2014
AbstractFatigue crack growth (FCG) could be encountered in many mechanical components, which can be made from either thin or thick steel plates (or shells) and, therefore, be subjected to a plane-stress or a plane-strain condition, respectively. The loads applied in a solid body containing a narrow notch or a sharp crack will induce a yield zone near ...
Chambel, Paulo, Martins, Rui F., Reis, Luís   +2 more
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Experimental and analytical study of cracks under biaxial fatigue [PDF]

, 2016
Most mechanical components experience multi-axial cyclic loading conditions during service. Experimental analysis of fatigue cracks under such conditions is not easy and most works tend to focus more on the simpler but less realistic case of uni-axial ...
Camas, Daniel, Lopez-Crespo, Pablo, Lopez-Moreno, A, Mokhtarishirazbad, M, Moreno-Morales, Maria Belen, Zanganeh, M   +5 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Distorting crack-front geometry for enhanced toughness by manipulating bioinspired heterogeneity

Nature Communications
Control of crack propagation is crucial to make tougher heterogeneous materials. As a crack interacts with material heterogeneities, its front distorts and adopts complex tortuous configurations.
Kaijin Wu, Zhaoqiang Song, Mengqi Liu, Zewen Wang, Si-Ming Chen, Shu-Hong Yu, Linghui He, Yong Ni   +7 more
doaj   +1 more source