Results 81 to 90 of about 133,565 (298)

Analytical modeling of surface roughness in precision grinding of particle reinforced metal matrix composites considering nanomechanical response of material [PDF]

, 2019
Grinding is usually applied for particle reinforced metal matrix composites (PRMMCs) to achieve high ground surface quality. However, the surface quality especially surface roughness is difficult to predict theoretically due to different mechanical ...
Cai, Rui, Huang, Chuanzhen, Wang, Jun, Yao, Peng, Zhang, Zhenzhong, Zhu, Hongtao   +5 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Analysis of Fatigue Crack Propagation of an Orthotropic Bridge Deck Based on the Extended Finite Element Method

Advances in Civil Engineering, 2019
As one of the most fatigue-sensitive parts of an orthotropic steel bridge deck, the weld between the U-rib and the top deck is prone to fatigue cracking under the actions of the stress concentration, welding residual stress, and vehicle load.
Ying Wang, Zhen Wang, Yuqian Zheng
doaj   +1 more source

Branching Instabilities in Rapid Fracture: Dynamics and Geometry

, 2004
We propose a theoretical model for branching instabilities in 2-dimensional fracture, offering predictions for when crack branching occurs, how multiple cracks develop, and what is the geometry of multiple branches.
Eran Bouchbinder, H. Schardin, Itamar Procaccia, J. F. Kalthoff, Joachim Mathiesen, L. B. Freund   +5 more
core   +1 more source

Concurrently coupled solid shell-based adaptive multiscale method for fracture [PDF]

, 2017
Artículo Open Access en el sitio web del editor. Pago por publicar en abierto.A solid shell-based adaptive atomistic–continuum numerical method is herein proposed to simulate complex crack growth patterns in thin-walled structures.
Budarapu, Pattabhi Ramaiah, Paggi, Marco, Reinoso Cuevas, José Antonio   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Random and Correlated Roughening in Slow Fracture by Damage Nucleation [PDF]

, 2006
We address the role of the nature of material disorder in determining the roughness of cracks which grow by damage nucleation and coalescence ahead of the crack tip.
Ben-Dayan, Ido, Bouchbinder, Eran, Procaccia, Itamar   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Study on Deflection of Delamination Crack under Mixed Mode II and III Failure Condition

Journal of the Japan Society for Composite Materials, 2011
Crack deflection behavior of delamination in composite laminates under general shear mode failure condition was studied by using DNSCB test method. For the specimens with starter cracks at 90°/90° interfaces, delamination crack was deflected at the top and bottom edges in opposite directions due to tensile principal stress in front of the crack.
Atsushi KONDO, Yuta SATO, Hiroshi SUEMASU, Katsuhisa GOUZU, Yuichiro AOKI   +4 more
openaire   +2 more sources