Results 61 to 70 of about 133,565 (298)
Use of cohesive elements in fatigue analysis [PDF]
, 2008 Cohesive laws describe the resistance to incipient separation of material surfaces. A cohesive finite element is formulated on the basis of a particular cohesive law.
Black, T. M. +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2021 A two-dimensional formulation of the 3-PG Model of implicit gradient elasticity has been developed in Part I. The predicted near-tip fields for Mode-I and Mode-II crack problems have been derived in Part II. It has been found that both the classical Cauchy stress and the nonclassical double stress are singular with the order of singularity r−12. In the
Carsten, Broese, +2 more
openaire +3 more sources
Simulation of subseismic joint and fault networks using a heuristic mechanical model [PDF]
, 2017 Flow simulations of fractured and faulted reservoirs require representation of subseismic structures about which subsurface data are limited. We describe a method for simulating fracture growth that is mechanically based but heuristic, allowing for ...
Casini, G +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Energies, 2020 Microwave-induced rock fracture is one of the promising approaches of achieving non-blasting continuous mining and assisted mechanical rock breaking.
Feng Gao, Yan Shao, Keping Zhou
doaj +1 more source
Crack front instabilities under mixed mode loading in three dimensions
, 2016 The evolution of a crack front under mixed mode loading (I+III) is studied using a phase field model in 3 dimensions with no stress boundary conditions. As previously observed experimentally in gels, there is a relaxation toward a geometry where $K_{III}=
Henry, Hervé
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Numerical Analysis for the Progressive Failure of Binary-Medium Interface under Shearing
Advances in Civil Engineering, 2018 Binary-medium specimens were fabricated using the particle flow code, and the shear strength, dilatancy, and failure behavior of the binary-medium specimens with different bond strength ratios (0.25, 0.5, 0.75, and 1.0) under different normal stresses ...
Rihong Cao +3 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source