Results 101 to 110 of about 133,565 (298)

Fatigue Crack Propagation Analysis of Rail Surface Under Mixed Initial Crack Patterns

Applied Sciences
Prolonged rolling contact fatigue between wheels and rails results in the formation of surface cracks on the rail and accurately analyzing the crack expansion behavior is essential to ensuring the safe operation of the train.
Jianhua Liu, Weiqi Yang, Zhongmei Wang
doaj   +1 more source

Fatigue Deformation and Energy Change of Single-Joint Sandstone After Freeze-Thaw Cycles and Cyclic Loadings

Frontiers in Earth Science, 2019
In cold regions, saturated fractured rock is prone to crack initiation, extension, and branching along the original fracture end under the effect of freeze-thaw (F-T) cycles and cyclic fatigue loadings. The resulting strength deterioration is accompanied
Yanjun Shen, Yanjun Shen, Yanjun Shen, Hongwei Yang, Long Jin, Huan Zhang, Gengshe Yang, Jinyuan Zhang   +7 more
doaj   +1 more source

Investigation of Lateral Stress Relief on theStability of PHI = 0 DEG Slopes Using Laboratory, Fracture Mechanics, and Finite Element Method Approaches [PDF]

, 2011
Total stress analyses of purely cohesive cut slopes utilize the undrained shear strength for slope stability analyses. These slopes can have an in-situ lateral earth pressure that is greater than the vertical pressure.
Kutschke, Walter
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Mixed Eulerian-Lagrangian Model for the Analysis of Dynamic Fracture [PDF]

, 1986
National Science Foundation Grant MEA 84 ...
Haber, R.B., Koh, H.M.
core  

The influence of toughening-particles in CFRPs on low velocity impact damage resistance performance

, 2014
The role of particle-toughening for increasing impact damage resistance in carbon fibre reinforced polymer (CFRP) composites was investigated. Five carbon fibre reinforced systems consisting of four particle-toughened matrices and one system containing ...
Bull, D.J., Scott, A.E., Sinclair, I., Spearing, S.M.   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Experimental study on I/II/III mixed mode fracture characteristics of a combined rock mass under creep loading

Scientific Reports
I/II/III mixed mode fractures of intersecting joint fissures often occur in natural rock masses, and jointed rock masses are prone to rockbursts in deep underground engineering when subjected to long-term crustal stresses.
Shuai Li, Chao Zheng, Peng Li, Shuo Zhang   +3 more
doaj   +1 more source